ArticleProceedings of the National Academy of Sciences of the United States of America1991
Heterogeneity of thymic epithelial cells in promoting T-lymphocyte differentiation in vivo.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 56 citations in OpenAlex.
- Foxn1 regulates lineage progression in cortical and medullary thymic epithelial cells but is dispensable for medullary sublineage divergence.PLoS genetics · 2011Article
- Overexpression of interleukin (IL)-7 leads to IL-15-independent generation of memory phenotype CD8+ T cells.The Journal of experimental medicine · 2002Article
- Transgenic expression of interleukin 7 restores T cell populations in nude mice.The Journal of experimental medicine · 1995Article
- Expression of LIF in transgenic mice results in altered thymic epithelium and apparent interconversion of thymic and lymph node morphologies.The EMBO journal · 1994Article
- Fetal liver and bone marrow JORO 75+ lymphocyte progenitors are precursors of CD4+8- TCR/CD3- early thymocytes.The Journal of experimental medicine · 1994Article
- Alterations of thymus cortical epithelium and interdigitating dendritic cells but no increase of thymocyte cell death in the early course of simian immunodeficiency virus infection.The American journal of pathology · 1993Article
- At day 8-8.5 of mouse development the yolk sac, not the embryo proper, has lymphoid precursor potential in vivo and in vitro.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Putative prethymic T cell precursors within the early human embryonic liver: a molecular and functional analysis.The Journal of experimental medicine · 1993Article
- Expression of cytokines and their receptors by human thymocytes and thymic stromal cells.Immunology · 1992Article
- In vitro differentiation of embryonic stem cells into lymphocyte precursors able to generate T and B lymphocytes in vivo.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- Article
- Differentiation of CD3-4-8- thymocytes in short-term thymic stromal cell culture.The Journal of experimental medicine · 1992Article
- Neuromodulatory loop mediated by nerve growth factor and interleukin 6 in thymic stromal cell cultures.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- Fetal liver pro-B and pre-B lymphocyte clones: expression of lymphoid-specific genes, surface markers, growth requirements, colonization of the bone marrow, and generation of B lymphocytes in vivo and in vitro.Molecular and cellular biology · 1992Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To study in vivo the contribution of different thymic epithelial cells to T-lymphocyte differentiation, we have established several nontransformed thymic epithelial cell lines and developed an in vivo assay, not involving exposure to drugs or radiation, that permitted us to study the capacity of these epithelial lines to support T-cell differentiation. We found that cell lines EA2 and ET, which express markers of cortical epithelial cells, produce interleukin 7 mRNA and after being injected into the spleens of young athymic nude mice support in vivo generation of CD4+CD8- T-cell receptor alpha beta+ T lymphocytes (ET line) or both CD4+CD8- and CD4-CD8+ T-cell receptor alpha beta+ T cells (EA2 line). Both cell lines also supported generation of T-cell receptor gamma delta+ T cells but appear not to support development of double-positive (CD4+CD8+) cells. One cell line, EB3, which expresses markers of medullary epithelial cells, produces interleukin 1 alpha RNA transcripts but does not support T-lymphocyte differentiation. The results provide direct evidence for functional heterogeneity of thymic epithelial cells in vivo and show the involvement of different cortical epithelial cells in the differentiation of T-cell progenitors into distinct thymocyte subsets.
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