ReviewCurrent opinion in structural biology2009
Macromolecular micromovements: how RNA polymerase translocates.
Review in Current opinion in structural biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Review
- Transcription pausing: biological significance of thermal fluctuations biased by repetitive genomic sequences.Transcription · 2018Article
- Bacterial RNA Polymerase-DNA Interaction-The Driving Force of Gene Expression and the Target for Drug Action.Frontiers in molecular biosciences · 2016Review
- RNA polymerase II transcriptional fidelity control and its functional interplay with DNA modifications.Critical reviews in biochemistry and molecular biology · 2015Review
- Molecular basis of transcriptional fidelity and DNA lesion-induced transcriptional mutagenesis.DNA repair · 2014Review
- Millisecond dynamics of RNA polymerase II translocation at atomic resolution.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Unveiling translocation intermediates of RNA polymerase.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Distinct conformations of a putative translocation element in poliovirus polymerase.Journal of molecular biology · 2014Article
- Thermodynamic modeling of variations in the rate of RNA chain elongation of E. coli rrn operons.Biophysical journal · 2014Article
- Molecular mechanisms of disease-causing missense mutations.Journal of molecular biology · 2013Review
- The interplay of structure and dynamics: insights from a survey of HIV-1 reverse transcriptase crystal structures.Proteins · 2013Article
- Understanding the Molecular Basis of RNA Polymerase II Transcription.Israel journal of chemistry · 2013Article
- A two-state model for the dynamics of the pyrophosphate ion release in bacterial RNA polymerase.PLoS computational biology · 2013Article
- RNA polymerase and the ribosome: the close relationship.Current opinion in microbiology · 2013Review
- X-ray crystal structure of Escherichia coli RNA polymerase σ70 holoenzyme.The Journal of biological chemistry · 2013Article
- Dynamics of pyrophosphate ion release and its coupled trigger loop motion from closed to open state in RNA polymerase II.Journal of the American Chemical Society · 2012Article
- Fitting experimental transcription data with a comprehensive template-dependent modular kinetic model.Biophysical journal · 2011Article
- Development of a "modular" scheme to describe the kinetics of transcript elongation by RNA polymerase.Biophysical journal · 2011Article
- Activity map of the Escherichia coli RNA polymerase bridge helix.The Journal of biological chemistry · 2011Article
- Allosteric suppression of HIV-1 reverse transcriptase structural dynamics upon inhibitor binding.Biophysical journal · 2011Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Multi-subunit DNA-dependent RNA polymerases synthesize RNA molecules thousands of nucleotides long. The reiterative reaction of nucleotide condensation occurs at rates of tens of nucleotides per second, invariably linked to the translocation of the enzyme along the DNA template, or threading of the DNA and the nascent RNA molecule through the enzyme. Reiteration of the nucleotide addition/translocation cycle without dissociation from the DNA and RNA requires both isomorphic and metamorphic conformational flexibility of a magnitude substantial enough to accommodate the requisite molecular motions. Here we review some of the more recently acquired insights into the structural flexibility and morphic fluctuations of RNA polymerases and their mechanistic implications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.