ArticleJournal of viral hepatitis2010
Genomic variability associated with the presence of occult hepatitis B virus in HIV co-infected individuals.
Article in Journal of viral hepatitis, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Characterization of genetic mutations in hepatitis B virus isolated from HBsAg+/HBcAb+/HBsAb-/HBV DNA + Japanese blood donors.Scientific reports · 2025Article
- Hepatitis B Virus (HBV) Infection and Re-activation During Nucleos(t)ide Reverse Transcriptase Inhibitor-Sparing Antiretroviral Therapy in a High-HBV Endemicity Setting.Open forum infectious diseases · 2018Article
- Article
- In Silico Analysis of Hepatitis B Virus Occult Associated Mutations in Botswana Using a Novel Algorithm.Genes · 2018Article
- Characteristics of escape mutations from occult hepatitis B virus infected patients with hematological malignancies in South Egypt.World journal of hepatology · 2017Article
- Occult hepatitis B virus infection in HIV positive patients at a tertiary healthcare unit in eastern India.PloS one · 2017Article
- Functional analysis of 'a' determinant mutations associated with occult HBV in HIV-positive South Africans.The Journal of general virology · 2016Article
- Occult Hepatitis B Virus Infection in a Previously Vaccinated Injection Drug User.Hepatitis monthly · 2016Article
- Characterization of Novel Hepatitis B Virus PreS/S-Gene Mutations in a Patient with Occult Hepatitis B Virus Infection.PloS one · 2016Article
- Mutations associated with occult hepatitis B in HIV-positive South Africans.Journal of medical virology · 2015Article
- Occult hepatitis B virus infection among Mexican human immunodeficiency virus-1-infected patients.World journal of gastroenterology · 2014Article
- HBV whole-genome mutation profile in HIV-1/HBV coinfected patients in a long-term follow-up study.Infection · 2014Article
- Potential mutations associated with occult hepatitis B virus status.Hepatitis monthly · 2014Review
- Mutations associated with occult hepatitis B virus infection result in decreased surface antigen expression in vitro.Journal of viral hepatitis · 2012Article
- Hepatitis B virus genotype G infection in a Turkish patient undergoing hemodialysis therapy.Hepatitis monthly · 2012Article
- Unusual presentation of hepatitis B serological markers in an Amerindian community of Venezuela with a majority of occult cases.Virology journal · 2011Article
- Hepatitis B virus (HBV) X gene diversity and evidence of recombination in HBV/HIV co-infected persons.Journal of medical virology · 2011Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Occult hepatitis B virus (O-HBV) infection is characterized by the presence of HBV DNA without detectable hepatitis B surface antigen (HBV DNA+/HBsAg-) in the serum. Although O-HBV is more prevalent during HBV/HIV co-infection, analysis of HBV mutations in co-infected patients is limited. In this preliminary study, HBV PreSurface (PreS) and surface (S) regions were amplified from 33 HIV-positive patient serum samples - 27 chronic HBV (C-HBV) and six O-HBV infections. HBV genotype was determined by phylogenetic analysis, while quasispecies diversity was quantified for the PreS, S and overlapping polymerase regions. C-HBV infections harboured genotypes A, D and G, compared to A, E, G and one mixed A/G infection for O-HBV. Interestingly, nonsynonymous-synonymous mutation values indicated positive immune selection in three regions for O-HBV vs one for C-HBV. Sequence analysis further identified new O-HBV mutations, in addition to several previously reported mutations within the HBsAg antigenic determinant. Several of these O-HBV mutations likely contribute to the lack of detectable HBsAg in O-HBV infection by interfering with detection in serologic assays, altering antigen secretion and/or decreasing replicative fitness.
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