ArticleMolecular microbiology2009
The cobinamide amidohydrolase (cobyric acid-forming) CbiZ enzyme: a critical activity of the cobamide remodelling system of Rhodobacter sphaeroides.
Article in Molecular microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 64 citations in OpenAlex.
- Novel chemistry and structural perspectives in vitamin BChemical science · 2026Review
- Addressing Vitamin BCommunications biology · 2026Article
- Cobalt and Vitamin B12 in Dairy Cattle Nutrition: Requirements, Functions, and Interactions.Animals : an open access journal from MDPI · 2025Review
- The Corrinoid Model for Dissecting Microbial Community Interactions Across Scales.Annual review of microbiology · 2025Review
- Laboratory evolution ofJournal of bacteriology · 2025Article
- Corrinoid salvaging and cobamide remodeling in bacteria and archaea.Journal of bacteriology · 2024Review
- Laboratory evolution ofbioRxiv : the preprint server for biology · 2024Article
- Soil microbial community response to corrinoids is shaped by a natural reservoir of vitamin BbioRxiv : the preprint server for biology · 2024Article
- Ligand cross-feeding resolves bacterial vitamin BNature · 2024Article
- Soil microbial community response to corrinoids is shaped by a natural reservoir of vitamin B12.The ISME journal · 2024Article
- Intraintestinal Analysis of the Functional Activity of Microbiomes and Its Application to the Common Marmoset Intestine.mSystems · 2022Article
- A Salvaging Strategy Enables Stable Metabolite Provisioning among Free-Living Bacteria.mSystems · 2022Article
- Uptake of Phytoplankton-Derived Carbon and Cobalamins by NovelApplied and environmental microbiology · 2022Article
- Remarkably coherent population structure for a dominant Antarctic Chlorobium species.Microbiome · 2021Article
- Direct Cobamide Remodeling via Additional Function of Cobamide Biosynthesis Protein CobS from Vibrio cholerae.Journal of bacteriology · 2021Article
- Article
- Relationship between Vitamin B12 and Cobalt Metabolism in Domestic Ruminant: An Update.Animals : an open access journal from MDPI · 2020Review
- Sharing vitamins: Cobamides unveil microbial interactions.Science (New York, N.Y.) · 2020Review
- Multi-faceted approaches to discovering and predicting microbial nutritional interactions.Current opinion in biotechnology · 2020Review
- Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The chemical structures of cobamides [cobalamin (Cbl)-like compounds] are the same, except for the lower ligand, which in adenosylcobalamin (AdoCbl) is 5,6-dimethylbenzimidazole, and in adenosylpseudocobalamin (AdopseudoCbl) is adenine. Why the lower ligand of cobamides varies and what the mechanism of lower ligand replacement is are long-standing questions in the field of B(12) biosynthesis. Work reported here uncovers the strategy used by the photosynthetic alpha-proteobacterium Rhodobacter sphaeroides to procure the cobamide it needs to grow on acetate as a carbon and energy source. On the basis of genetic and biochemical evidence we conclude that, in R. sphaeroides, the activity of the cobyric acid-producing amidohydrolase CbiZ enzyme is essential for the conversion of AdopseudoCbl into AdoCbl, the cobamide needed for the catabolism of acetate. The CbiZ enzyme uses AdopseudoCbl as a substrate, but not AdoCbl. Implications of these findings for cobamide remodelling in R. sphaeroides and in other CbiZ-containing microorganisms are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.