ArticleHelicobacter2009
Detection of Helicobacter hepaticus in human bile samples of patients with biliary disease.
Article in Helicobacter, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- The Relationship betweenCanadian journal of gastroenterology & hepatology · 2021Pooled it
- Are Helicobacter pylori and other Helicobacter species infection associated with human biliary lithiasis? A meta-analysis.PloS one · 2011Pooled it
- Article
- Helicobacter hepaticus augmentation triggers Dopaminergic degeneration and motor disorders in mice with Parkinson's disease.Molecular psychiatry · 2023Article
- Validation of Multiplex PCR and Serology DetectingMicroorganisms · 2023Article
- Effect of Long-Term and Short-Term Imbalanced Zn Manipulation on Gut Microbiota and Screening for Microbial Markers Sensitive to Zinc Status.Microbiology spectrum · 2021Article
- Article
- Microbe-Driven Genotoxicity in Gastrointestinal Carcinogenesis.International journal of molecular sciences · 2020Review
- Gallstone Disease and Microbiome.Microorganisms · 2020Review
- Oral and intestinal bacterial exotoxins: Potential linked to carcinogenesis.Progress in molecular biology and translational science · 2020Review
- Helicobacter infection in the hepatobiliary system and hepatic lesions: a possible association in dogs.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2019Article
- Plasma Helicobacter pylori Antibody Titers and Helicobacter pylori Infection Positivity Rates in Patients with Gallbladder Cancer or Cholelithiasis: a Hospital-Based Case-Control StudyAsian Pacific journal of cancer prevention : APJCP · 2018Article
- Is There a Correlation betweenMiddle East journal of digestive diseases · 2018Article
- Interactions between Bacteria and Bile Salts in the Gastrointestinal and Hepatobiliary Tracts.Frontiers in medicine · 2017Review
- Vitamin D Signaling through Induction of Paneth Cell Defensins Maintains Gut Microbiota and Improves Metabolic Disorders and Hepatic Steatosis in Animal Models.Frontiers in physiology · 2016Article
- The Detection of Helicobacter hepaticus Using Whispering-Gallery Mode Microcavity Optical Sensors.Biosensors · 2015Article
- Helicobacter hepaticus cholesterol-α-glucosyltransferase is essential for establishing colonization in male A/JCr mice.Helicobacter · 2014Article
- Helicobacter pylori infection is positively associated with gallstones: a large-scale cross-sectional study in Japan.Journal of gastroenterology · 2014Article
- Helicobacter hepaticus, a new pathogenic species of the Helicobacter genus: Similarities and differences with H. pylori.Iranian journal of microbiology · 2013Review
- Effects of Helicobacter pylori γ-glutamyltranspeptidase on apoptosis and inflammation in human biliary cells.Digestive diseases and sciences · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSince the discovery of Helicobacter pylori, various enterohepatic Helicobacter spices have been detected in the guts of humans and animals. Some enterohepatic Helicobacters have been associated with inflammatory bowel disease or liver disease in mice. However the association of these bacteria with human diseases remains unknown. MATERIALS AND
methodsWe collected 126 bile samples from patients with cholelithiasis, cholecystitis, gallbladder polyp, and other nonbiliary diseases. Samples were screened for the presence of enterohepatic Helicobacter spp. using cultures, nested PCR, or in situ hybridization. We tested for antibodies to H. pylori and H. hepaticus by Western blot analysis.
resultsAttempts at cultivation were unsuccessful. However, H. hepaticus was detected in bile samples with nested PCR whereas H. bilis was not. Helicobacter hepaticus in the bile was confirmed by in situ hybridization, but H. hepaticus from bile samples was coccoid in appearance. We detected immunoglobulin G antibodies to H. hepaticus in bile samples by Western blotting. Helicobacter hepaticus was detected in 40 (32%) of total 126 samples as H. hepaticus positive if at least one of the three methods with nested PCR, in situ, or Western blotting. Patients with cholelithiasis (41%) and cholecystitis with gastric cancer (36%) had significantly higher (p = .029) prevalence of H. hepaticus infection than samples from patients with other diseases.
conclusionHelicobacter hepaticus may closely associate with diseases of the liver and biliary tract in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.