Evidence map›Paper›PMID 19888720›Full record

ArticleNano letters2009

Supramolecular protein cage composite MR contrast agents with extremely efficient relaxivity properties.

Lars O Liepold, Md Joynal Abedin, Emily D Buckhouse, Joseph A Frank, Mark J Young, Trevor Douglas

Abstract read
In one paragraph

Article in Nano letters, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Molecular basis for protein-protein interactions.Beilstein journal of organic chemistry · 2021
    Review
  5. Supramolecular Metallacycles and Their Binding of Fullerenes.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020
    Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Manganese(III) porphyrins complexed with P22 virus-like particles as T1-enhanced contrast agents for magnetic resonance imaging.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2014
    Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Target binding improves relaxivity in aptamer-gadolinium conjugates.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2012
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lars O LiepoldDepartment of Chemistry and Biochemistry, Center for BioInspired Nanomaterials, Montana State University, Bozeman, Montana, USA.
Md Joynal Abedin
Emily D Buckhouse
Joseph A Frank
Mark J Young
Trevor Douglas

Funding

Targeted MRI with Protein Cage Architectures (RMI)R21EB005364 · NIBIB · MONTANA STATE UNIVERSITY - BOZEMAN · PI DOUGLAS, TREVOR · 2005 to 2008
$1.4M
Development And Evaluation Of Magnetic Resonance Contrast AgentsZIACL090004 · CLC · CLINICAL CENTER · PI FRANK, JOSEPH · 2009 to 2015
$0k
Intramural NIH HHS ZIA CL090004NIBIB NIH HHS R21 EB005364NIBIB NIH HHS R21EB005364
6 · The paper itself

Abstract

A DTPA-Gd containing polymer was grown in the interior of a heat shock protein cage resulting in T(1) particle relaxivities of 4200 mM(-1) sec(-1) for the 12 nm particle. Relaxivity parameters were determined, and this analysis suggests that the rotational correlation time has been optimized while the water exchange lifetime is longer than optimal. This synthetic approach holds much promise for the development of next generation contrast agents and this report will aid in their design.

Indexed as

Contrast MediaDrug CarriersGadolinium DTPAHeat-Shock ProteinsImage EnhancementMagnetic Resonance ImagingMultiprotein ComplexesPhantoms, ImagingContrast MediaDrug CarriersGadolinium DTPAHeat-Shock ProteinsMultiprotein Complexes

Identifiers

PMID19888720
PMCPMC3625947

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.