ArticleJournal of diabetes science and technology2007
The artificial pancreas: how sweet engineering will solve bitter problems.
Article in Journal of diabetes science and technology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 83 citations in OpenAlex.
- Artificial Pancreas: The First 20 Years.Journal of diabetes science and technology · 2025Article
- Accuracy of CGM Systems During Continuous and Interval Exercise in Adults with Type 1 Diabetes.Journal of diabetes science and technology · 2022Article
- Diabetes Technology: Monitoring, Analytics, and Optimal Control.Cold Spring Harbor perspectives in medicine · 2019Review
- Automated closed-loop control of diabetes: the artificial pancreas.Bioelectronic medicine · 2018Review
- Using LSTMs to learn physiological models of blood glucose behavior.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2017Article
- Analysis of the Accuracy and Performance of a Continuous Glucose Monitoring Sensor Prototype: An In-Silico Study Using the UVA/PADOVA Type 1 Diabetes Simulator.Journal of diabetes science and technology · 2017Article
- Report from IPITA-TTS Opinion Leaders Meeting on the Future of β-Cell Replacement.Transplantation · 2016Article
- Assessing sensor accuracy for non-adjunct use of continuous glucose monitoring.Diabetes technology & therapeutics · 2015Article
- Interstitium versus Blood Equilibrium in Glucose Concentration and its Impact on Subcutaneous Continuous Glucose Monitoring Systems.European endocrinology · 2014Article
- DiAs user interface: a patient-centric interface for mobile artificial pancreas systems.Journal of diabetes science and technology · 2013Article
- Modular closed-loop control of diabetes.IEEE transactions on bio-medical engineering · 2012Article
- Diabetes technology: markers, monitoring, assessment, and control of blood glucose fluctuations in diabetes.Scientifica · 2012Review
- Artificial pancreas: past, present, future.Diabetes · 2011Review
- Smart sensors for maintaining physiologic homeostasis.Journal of diabetes science and technology · 2011Article
- Multinational study of subcutaneous model-predictive closed-loop control in type 1 diabetes mellitus: summary of the results.Journal of diabetes science and technology · 2010Article
- Critical role of tissue mast cells in controlling long-term glucose sensor function in vivo.Biomaterials · 2010Article
- Progress in development of an artificial pancreas.Journal of diabetes science and technology · 2009Article
- Run-to-run tuning of model predictive control for type 1 diabetes subjects: in silico trial.Journal of diabetes science and technology · 2009Article
- Health technology assessment review: Computerized glucose regulation in the intensive care unit--how to create artificial control.Critical care (London, England) · 2009Review
- Recent progress in mechanical artificial pancreas.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An artificial pancreas is a closed-loop system containing only synthetic materials which substitutes for an endocrine pancreas. No artificial pancreas system is currently approved; however, devices that could become components of such a system are now becoming commercially available. An artificial pancreas will consist of functionally integrated components that will continuously sense glucose levels, determine appropriate insulin dosages, and deliver the insulin. Any proposed closed loop system will be closely scrutinized for its safety, efficacy, and economic impact. Closed loop control utilizes models of glucose homeostasis which account for the influences of feeding, stress, insulin, exercise, and other factors on blood glucose levels. Models are necessary for understanding the relationship between blood glucose levels and insulin dosing; developing algorithms to control insulin dosing; and customizing each user's system based on individual responses to factors that influence glycemia. Components of an artificial pancreas are now being developed, including continuous glucose sensors; insulin pumps for parenteral delivery; and control software, all linked through wireless communication systems. Although a closed-loop system providing glucagon has not been reported in 40 years, the use of glucagon to prevent hypoglycemia is physiologically attractive and future devices might utilize this hormone. No demonstration of long-term closed loop control of glucose in a free-living human with diabetes has been reported to date, but many centers around the world are working on closed loop control systems. It is expected that many types of artificial pancreas systems will eventually be available, and they will greatly benefit patients with diabetes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.