ReviewInternational journal of chronic obstructive pulmonary disease2009
Long-term therapy in COPD: any evidence of adverse effect on bone?
Review in International journal of chronic obstructive pulmonary disease, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Copd.BMJ clinical evidence · 2011Pooled it
- Prednisolone in COPD: the overlooked harm.The British journal of general practice : the journal of the Royal College of General Practitioners · 2024Article
- The role of autophagy in controlling SARS-CoV-2 infection: An overview on virophagy-mediated molecular drug targets.Cell biology international · 2021Review
- Musculoskeletal Disorders in Chronic Obstructive Airway Diseases: A Neglected Clinical Entity.Mediterranean journal of rheumatology · 2021Review
- Autophagy and SARS-CoV-2 infection: Apossible smart targeting of the autophagy pathway.Virulence · 2020Article
- The risk of osteoporosis in patients with asthma.European clinical respiratory journal · 2020Review
- Women and COPD: do we need more evidence?European respiratory review : an official journal of the European Respiratory Society · 2019Review
- Call to action: improving primary care for women with COPD.NPJ primary care respiratory medicine · 2017Review
- Osteoporosis in chronic obstructive pulmonary disease.Clinical medicine insights. Circulatory, respiratory and pulmonary medicine · 2015Review
- Musculoskeletal disorders in chronic obstructive pulmonary disease.BioMed research international · 2014Review
- Cross-sectional associations between prevalent vertebral fracture and pulmonary function in the sixth Tromsø study.BMC geriatrics · 2013Observational
- Bone protection in chronic obstructive pulmonary disease (COPD) patients requiring regular intermittent glucocorticoid therapy.Clinical medicine (London, England) · 2013Article
- Risk-to-benefit ratio of inhaled corticosteroids in patients with COPD.Primary care respiratory journal : journal of the General Practice Airways Group · 2013Review
- Optimizing safety of COPD treatments: role of the nurse practitioner.Journal of multidisciplinary healthcare · 2013Article
- Effect of weight loss in adults on estimation of risk due to adiposity in a cohort study.Obesity (Silver Spring, Md.) · 2012Article
- Recommendations for Diagnosis and Management of Osteoporosis in COPD Men.ISRN rheumatology · 2011Article
- Towards Rational Prescription of Common Inhaler Medication in the Multimorbid COPD Patient.International journal of chronic obstructive pulmonary diseaseArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients with COPD have high risk for osteoporosis and fractures. Hip and vertebral fractures might impair mobility, and vertebral fractures further reduce lung function. This review discusses the evidence of bone loss due to medical treatment opposed to disease severity and risk factors for COPD, and therapeutic options for the prevention and treatment of osteoporosis in these patients. A review of the English-language literature was conducted using the MEDLINE database until June 2009. Currently used bronchodilators probably lack adverse effect on bone. Oral corticosteroids (OCS) increase bone resorption and decrease bone formation in a dose response relationship, but the fracture risk is increased more than reflected by bone densitometry. Inhaled corticosteroids (ICS) have been associated with both increased bone loss and fracture risk. This might be a result of confounding by disease severity, but high doses of ICS have similar effects as equipotent doses of OCS. The life-style factors should be modified, use of regular OCS avoided and use of ICS restricted to those with evidenced effect and probably kept at moderate doses. The health care should actively reveal risk factors, include bone densitometry in fracture risk evaluation, and give adequate prevention and treatment for osteoporosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.