ReviewEuropean journal of human genetics : EJHG2010
Ethical implications of the use of whole genome methods in medical research.
Review in European journal of human genetics : EJHG, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- To tell or not to tell? A systematic review of ethical reflections on incidental findings arising in genetics contexts.European journal of human genetics : EJHG · 2013Pooled it
- Use of next generation sequencing technologies in research and beyond: are participants with mental health disorders fully protected?BMC medical ethics · 2012Pooled it
- Ethical Challenges of Obtaining Informed Consent: Qualitative Research on the Perspectives of Tuberculosis Patients Participating in Human Genomic Research in Ethiopia.Developing world bioethics · 2026Article
- Harnessing the power of clinical decision support systems: challenges and opportunities.Open heart · 2023Review
- A data harmonization pipeline to leverage external controls and boost power in GWAS.Human molecular genetics · 2022Article
- Australian human research ethics committee members' confidence in reviewing genomic research applications.European journal of human genetics : EJHG · 2021Article
- Becoming partners, retaining autonomy: ethical considerations on the development of precision medicine.BMC medical ethics · 2016Article
- Unsolicited findings of next-generation sequencing for tumor analysis within a Dutch consortium: clinical daily practice reconsidered.European journal of human genetics : EJHG · 2016Article
- Addressing ethical challenges in the Genetics Substudy of the National Eye Survey of Trinidad and Tobago (GSNESTT).Applied & translational genomics · 2016Article
- A Method to Exploit the Structure of Genetic Ancestry Space to Enhance Case-Control Studies.American journal of human genetics · 2016Article
- Respecting Autonomy Over Time: Policy and Empirical Evidence on Re-Consent in Longitudinal Biomedical Research.Bioethics · 2016Article
- Article
- Ethical considerations of research policy for personal genome analysis: the approach of the Genome Science Project in Japan.Life sciences, society and policy · 2014Article
- Consenting for current genetic research: is Canadian practice adequate?BMC medical ethics · 2014Article
- Genetic counseling practice in next generation sequencing research: implications for the ethical oversight of the informed consent process.Journal of genetic counseling · 2014Article
- Incidental findings from clinical genome-wide sequencing: a review.Journal of genetic counseling · 2014Review
- Incidental findings: the time is not yet ripe for a policy for biobanks.European journal of human genetics : EJHG · 2014Article
- Re-contacting participants for inclusion in the database of Genotypes and Phenotypes (dbGaP): Findings from three case-control studies of lung cancer.Genome medicine · 2014Article
- Current status, challenges, policies, and bioethics of biobanks.Genomics & informatics · 2013Review
- Role of non-HLA gene polymorphisms in graft-versus-host disease.International journal of hematology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The use of genome-wide association studies (GWAS) in medical research and the increased ability to share data give a new twist to some of the perennial ethical issues associated with genomic research. GWAS create particular challenges because they produce fine, detailed, genotype information at high resolution, and the results of more focused studies can potentially be used to determine genetic variation for a wide range of conditions and traits. The information from a GWA scan is derived from DNA that is a powerful personal identifier, and can provide information not just on the individual, but also on the individual's relatives, related groups, and populations. Furthermore, it creates large amounts of individual-specific digital information that is easy to share across international borders. This paper provides an overview of some of the key ethical issues around GWAS: consent, feedback of results, privacy, and the governance of research. Many of the questions that lie ahead of us in terms of the next generation sequencing methods will have been foreshadowed by GWAS and the debates around ethical and policy issues that these have created.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.