ArticleNeuroendocrinology2010
Estrogen-induced sexual incentive motivation, proceptivity and receptivity depend on a functional estrogen receptor alpha in the ventromedial nucleus of the hypothalamus but not in the amygdala.
Article in Neuroendocrinology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 69 citations in OpenAlex.
- Hypothalamic Estrogen Receptor α Is Essential for Female Marmoset Sexual Behavior Without Protecting From Obesity.Journal of the Endocrine Society · 2025Article
- Neuroendocrinology of sexual behavior.International journal of impotence research · 2024Review
- Reproductive function and behaviors: an update on the role of neural estrogen receptors alpha and beta.Frontiers in endocrinology · 2024Review
- The elusive concept of sexual motivation: can it be anchored in the nervous system?Frontiers in neuroscience · 2023Review
- Aromatase Inhibition Eliminates Sexual Receptivity Without Enhancing Weight Gain in Ovariectomized Marmoset Monkeys.Journal of the Endocrine Society · 2022Article
- EDCs Reorganize Brain-Behavior Phenotypic Relationships in Rats.Journal of the Endocrine Society · 2021Article
- Exposure to prenatal PCBs shifts the timing of neurogenesis in the hypothalamus of developing rats.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2020Article
- Prenatal EDCs Impair Mate and Odor Preference and Activation of the VMN in Male and Female Rats.Endocrinology · 2020Article
- Effects of the Endocrine-Disrupting Chemicals, Vinclozolin and Polychlorinated Biphenyls, on Physiological and Sociosexual Phenotypes in F2 Generation Sprague-Dawley Rats.Environmental health perspectives · 2018Article
- Nest box exploration may stimulate breeding physiology and alter mRNA expression in the medial preoptic area of female European starlings.The Journal of experimental biology · 2018Article
- A cooperative function for multisensory stimuli in the induction of approach behavior of a potential mate.PloS one · 2017Article
- Circuit modules linking internal states and social behaviour in flies and mice.Nature reviews. Neuroscience · 2016Review
- Chronic social isolation enhances reproduction in the monogamous prairie vole (Microtus ochrogaster).Psychoneuroendocrinology · 2016Article
- Genetic dissection of neural circuits underlying sexually dimorphic social behaviours.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- Scalable control of mounting and attack by Esr1+ neurons in the ventromedial hypothalamus.Nature · 2014Article
- Epigenetic changes in the estrogen receptor α gene promoter: implications in sociosexual behaviors.Frontiers in neuroscience · 2014Review
- Social isolation during puberty affects female sexual behavior in mice.Frontiers in behavioral neuroscience · 2014Article
- Sex differences in the physiology of eating.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Review
- Animal Models for the Study of Female Sexual Dysfunction.Sexual medicine reviews · 2013Review
- Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
The display of copulatory behaviors usually requires the presence of a mate and is, therefore, preceded by a search for and approach to a potential partner. The intensity of approach behaviors is determined by a process labeled sexual incentive motivation. Although it is known that female sexual motivation depends on estrogens, their site of action within the brain is unknown. In the present experiment, we obtained data relevant to this issue. An shRNA encoded within an adeno-associated viral (AAV) vector directed against the estrogen receptor alpha (ERalpha) gene (or containing a nonsense base sequence as a control treatment) was injected bilaterally into the ventromedial nucleus of the hypothalamus (VMN) or the posterodorsal amygdala (MePDA) of female rats. After an 80% reduction of the number of ERalpha in the VMN, sexual incentive motivation was absent after treatment with estradiol and progesterone. Proceptivity and receptivity were also much reduced, while the number of rejections was enhanced. Suppression of the ERalpha in the MePDA lacked these effects. Likewise, the inactive control AAV vector failed to modify any behavior. Thus, the ERalpha in the VMN, but not in the MePDA, is important for proceptivity and receptivity as well as for sexual incentive motivation. These results show that ERalpha in the VMN is crucial for the entire sequence of behavioral events from the processes leading to the establishment of sexual contact until the accomplishment of copulatory behaviors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.