ArticleProceedings of the National Academy of Sciences of the United States of America2009
Cellular stress created by intermediary metabolite imbalances.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 56 citations in OpenAlex.
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- Regulation of Microbial Metabolic Rates Using CRISPR Interference With Expanded PAM Sequences.Frontiers in microbiology · 2020Article
- Overexpression of UDP-Glucose 4-Epimerase Is Associated with Differentiation Grade of Gastric Cancer.Disease markers · 2019Article
- Sugar and iron: Toward understanding the antibacterial effect of ciclopirox in Escherichia coli.PloS one · 2019Article
- Translational regulation by bacterial small RNAs via an unusual Hfq-dependent mechanism.Nucleic acids research · 2018Article
- Recent Developments of the Synthetic Biology Toolkit forFrontiers in microbiology · 2018Review
- A metabolic intermediate of the fructose-asparagine utilization pathway inhibits growth of a Salmonella fraB mutant.Scientific reports · 2016Article
- Cellular Growth Arrest and Persistence from Enzyme Saturation.PLoS computational biology · 2016Article
- Phenotypic Characterization Analysis of Human Hepatocarcinoma by Urine Metabolomics Approach.Scientific reports · 2016Article
- Diverse mechanisms of post-transcriptional repression by the small RNA regulator of glucose-phosphate stress.Molecular microbiology · 2016Article
- Molecular Mechanisms of Transcription Initiation at gal Promoters and their Multi-Level Regulation by GalR, CRP and DNA Loop.Biomolecules · 2015Review
- Single nucleotide resolution RNA-seq uncovers new regulatory mechanisms in the opportunistic pathogen Streptococcus agalactiae.BMC genomics · 2015Article
- Mutations in transcriptional regulators allow selective engineering of signal integration logic.mBio · 2014Article
- Article
- Short-term differential adaptation to anaerobic stress via genomic mutations by Escherichia coli strains K-12 and B lacking alcohol dehydrogenase.Frontiers in microbiology · 2014Article
- The small RNA SgrS: roles in metabolism and pathogenesis of enteric bacteria.Frontiers in cellular and infection microbiology · 2014Review
- Depletion of glycolytic intermediates plays a key role in glucose-phosphate stress in Escherichia coli.Journal of bacteriology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 4 countries.
Funding
Abstract
Small molecules generally activate or inhibit gene transcription as externally added substrates or as internally accumulated end-products, respectively. Rarely has a connection been made that links an intracellular intermediary metabolite as a signal of gene expression. We report that a perturbation in the critical step of a metabolic pathway--the D-galactose amphibolic pathway--changes the dynamics of the pathways leading to accumulation of the intermediary metabolite UDP-galactose. This accumulation causes cell stress and transduces signals that alter gene expression so as to cope with the stress by restoring balance in the metabolite pool. This underscores the importance of studying the global effects of alterations in the level of intermediary metabolites in causing stress and coping with it by transducing signals to genes to reach a stable state of equilibrium (homeostasis). Such studies are an essential component in the integration of metabolomics, proteomics, and transcriptomics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.