ArticleCancer research2009
Pattern of antioxidant and DNA repair gene expression in normal airway epithelium associated with lung cancer diagnosis.
Article in Cancer research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 66 citations in OpenAlex.
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- Microsomal glutathione transferase 1 confers cisplatin resistance of non-small cell lung cancer via interaction with arachidonate lipoxygenase 5 to repress ferroptosis.Iranian journal of basic medical sciences · 2025Article
- Inflammation in the tumor-adjacent lung as a predictor of clinical outcome in lung adenocarcinoma.Nature communications · 2023Article
- Review
- TP53 mutation prevalence in normal airway epithelium as a biomarker for lung cancer risk.BMC cancer · 2023Article
- CEBPG suppresses ferroptosis through transcriptional control of SLC7A11 in ovarian cancer.Journal of translational medicine · 2023Article
- Microsomal glutathione transferase 1 in cancer and the regulation of ferroptosis.Advances in cancer research · 2023Review
- Deciphering cell lineage specification of human lung adenocarcinoma with single-cell RNA sequencing.Nature communications · 2021Article
- CEBPG promotes acute myeloid leukemia progression by enhancing EIF4EBP1.Cancer cell international · 2021Article
- CEBPγ facilitates lamellipodia formation and cancer cell migration through CERS6 upregulation.Cancer science · 2021Article
- Persistent DNA damage triggers activation of the integrated stress response to promote cell survival under nutrient restriction.BMC biology · 2020Article
- CEBPG promotes esophageal squamous cell carcinoma progression by enhancing PI3K-AKT signaling.American journal of cancer research · 2020Article
- MicroRNA BiomarkerInternational journal of genomics · 2020Article
- Article
- Biomarkers in Lung Cancer Screening: Achievements, Promises, and Challenges.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2019Review
- The Airway Transcriptome as a Biomarker for Early Lung Cancer Detection.Clinical cancer research : an official journal of the American Association for Cancer Research · 2018Review
- RNAseq analysis of bronchial epithelial cells to identify COPD-associated genes and SNPs.BMC pulmonary medicine · 2018Article
- Article
- Shared Gene Expression Alterations in Nasal and Bronchial Epithelium for Lung Cancer Detection.Journal of the National Cancer Institute · 2017Article
- A lung cancer risk classifier comprising genome maintenance genes measured in normal bronchial epithelial cells.BMC cancer · 2017Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
In previous studies, we reported that key antioxidant and DNA repair genes are regulated differently in normal bronchial epithelial cells of lung cancer cases compared with non-lung cancer controls. In an effort to develop a biomarker for lung cancer risk, we evaluated the transcript expressions of 14 antioxidant, DNA repair, and transcription factor genes in normal bronchial epithelial cells (HUGO names CAT, CEBPG, E2F1, ERCC4, ERCC5, GPX1, GPX3, GSTM3, GSTP1, GSTT1, GSTZ1, MGST1, SOD1, and XRCC1). A test comprising these 14 genes accurately identified the lung cancer cases in two case-control studies. The receiver operating characteristic-area under the curve was 0.82 (95% confidence intervals, 0.68-0.91) for the first case-control set (25 lung cancer cases and 24 controls), and 0.87 (95% confidence intervals, 0.73-0.96) for the second set (18 cases and 22 controls). For each gene included in the test, the key difference between cases and controls was altered distribution of transcript expression among cancer cases compared with controls, with more lung cancer cases expressing at both extremes among all genes (Kolmorogov-Smirnov test, D = 0.0795; P = 0.041). A novel statistical approach was used to identify the lower and upper boundaries of transcript expression that optimally classifies cases and controls for each gene. Based on the data presented here, there is an increased prevalence of lung cancer diagnosis among individuals that express a threshold number of key antioxidant, DNA repair, and transcription factor genes at either very high or very low levels in the normal airway epithelium.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.