ArticleJournal of cell science2009
Determinism and divergence of apoptosis susceptibility in mammalian cells.
Article in Journal of cell science, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Inheritable cell-states shape drug-persister correlations and population dynamics in cancer cells.PLoS computational biology · 2025Article
- Factors that determine cell fate in mitotically arrested cancer cells.Frontiers in cell and developmental biology · 2025Article
- Live-cell imaging and mathematical analysis of the "community effect" in apoptosis.Apoptosis : an international journal on programmed cell death · 2023Article
- Quantifying cancer cell plasticity with gene regulatory networks and single-cell dynamics.Frontiers in network physiology · 2023Review
- A single-cell micro-trench platform for automatic monitoring of cell division and apoptosis after chemotherapeutic drug administration.Scientific reports · 2018Article
- Hidden heterogeneity and circadian-controlled cell fate inferred from single cell lineages.Nature communications · 2018Article
- Mitochondrial levels determine variability in cell death by modulating apoptotic gene expression.Nature communications · 2018Article
- NF-κB signalling and cell fate decisions in response to a short pulse of tumour necrosis factor.Scientific reports · 2016Article
- Cross-Species Rhesus Cytomegalovirus Infection of Cynomolgus Macaques.PLoS pathogens · 2016Article
- Functionally identifiable apoptosis-insensitive subpopulations determine chemoresistance in acute myeloid leukemia.The Journal of clinical investigation · 2016Article
- Going Viral with Fluorescent Proteins.Journal of virology · 2015Review
- Surviving apoptosis: life-death signaling in single cells.Trends in cell biology · 2015Review
- Temporal Heterogeneity Metrics in Apoptosis Induced by Anticancer Drugs.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2015Article
- Fractional killing arises from cell-to-cell variability in overcoming a caspase activity threshold.Molecular systems biology · 2015Article
- Capsaicin as an inducer of damage-associated molecular patterns (DAMPs) of immunogenic cell death (ICD) in human bladder cancer cells.Cell stress & chaperones · 2013Article
- Cells surviving fractional killing by TRAIL exhibit transient but sustainable resistance and inflammatory phenotypes.Molecular biology of the cell · 2013Article
- Modulating cell-to-cell variability and sensitivity to death ligands by co-drugging.Physical biology · 2013Article
- Detecting soluble polyQ oligomers and investigating their impact on living cells using split-GFP.Methods in molecular biology (Clifton, N.J.) · 2013Article
- STL-based analysis of TRAIL-induced apoptosis challenges the notion of type I/type II cell line classification.PLoS computational biology · 2013Article
- A network-oriented perspective on cardiac calcium signaling.American journal of physiology. Cell physiology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Although the cellular decision to commit to apoptosis is important for organism homeostasis, there is considerable variability in the onset of apoptosis between cells, even in clonal populations. Using live single-cell imaging, we observed that the onset of apoptotic proteolytic activity was tightly synchronized between nearby cells. This synchrony was not a consequence of secreted factors and was not correlated to the cell cycle. The synchrony was only seen amongst related cells and was lost over successive generations. The times of apoptosis also diverged within a generation, but this was blocked by inhibiting protein synthesis before triggering apoptosis. These results suggest that the cell-cell variability of apoptosis times is due to the divergence of the molecular composition of the cell, and that the decision to commit to apoptosis at the time of drug addition is a deterministic decision.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.