ArticleJournal of experimental botany2010
A nematode effector protein similar to annexins in host plants.
Article in Journal of experimental botany, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 131 citations in OpenAlex.
- Molecular Mechanisms ofInternational journal of molecular sciences · 2026Article
- A catalogue of virulence strategies mediated by phytopathogenic effectors.Fundamental research · 2025Review
- Evolution of parasitism genes in the plant parasitic nematodes.Scientific reports · 2024Article
- The Wheat AnnexinInternational journal of molecular sciences · 2023Article
- Genome-wide characterization of 2OGD superfamily for mining of susceptibility factors responding to various biotic stresses inPhysiology and molecular biology of plants : an international journal of functional plant biology · 2023Article
- A tale of many families: calcium channels in plant immunity.The Plant cell · 2022Review
- Article
- Inhibition of acetyl-CoA carboxylase by spirotetramat causes growth arrest and lipid depletion in nematodes.Scientific reports · 2020Article
- A MIF-like effector suppresses plant immunity and facilitates nematode parasitism by interacting with plant annexins.Journal of experimental botany · 2019Article
- Molecular Basis of Soybean Resistance to Soybean Aphids and Soybean Cyst Nematodes.Plants (Basel, Switzerland) · 2019Review
- Host-derived gene silencing of parasite fitness genes improves resistance to soybean cyst nematodes in stable transgenic soybean.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2019Article
- Two venom allergen-like proteins, HaVAP1 and HaVAP2, are involved in the parasitism of Heterodera avenae.Molecular plant pathology · 2019Article
- Plant Proteins and Processes Targeted by Parasitic Nematode Effectors.Frontiers in plant science · 2019Review
- Article
- The plant-parasitic cyst nematode effector GLAND4 is a DNA-binding protein.Molecular plant pathology · 2018Article
- Signal Transduction in Plant⁻Nematode Interactions.International journal of molecular sciences · 2018Review
- Nematode-secreted peptides and host factor mimicry.Journal of experimental botany · 2018Article
- Novel global effector mining from the transcriptome of early life stages of the soybean cyst nematode Heterodera glycines.Scientific reports · 2018Article
- "Cyst-ained" research into Heterodera parasitism.PLoS pathogens · 2018Review
- Rational design of biosafe crop resistance to a range of nematodes using RNA interference.Plant biotechnology journal · 2018Article
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nematode parasitism genes encode secreted effector proteins that play a role in host infection. A homologue of the expressed Hg4F01 gene of the root-parasitic soybean cyst nematode, Heterodera glycines, encoding an annexin-like effector, was isolated in the related Heterodera schachtii to facilitate use of Arabidopsis thaliana as a model host. Hs4F01 and its protein product were exclusively expressed within the dorsal oesophageal gland secretory cell in the parasitic stages of H. schachtii. Hs4F01 had a 41% predicted amino acid sequence identity to the nex-1 annexin of C. elegans and 33% identity to annexin-1 (annAt1) of Arabidopsis, it contained four conserved domains typical of the annexin family of calcium and phospholipid binding proteins, and it had a predicted signal peptide for secretion that was present in nematode annexins of only Heterodera spp. Constitutive expression of Hs4F01 in wild-type Arabidopsis promoted hyper-susceptibility to H. schachtii infection. Complementation of an AnnAt1 mutant by constitutive expression of Hs4F01 reverted mutant sensitivity to 75 mM NaCl, suggesting a similar function of the Hs4F01 annexin-like effector in the stress response by plant cells. Yeast two-hybrid assays confirmed a specific interaction between Hs4F01 and an Arabidopsis oxidoreductase member of the 2OG-Fe(II) oxygenase family, a type of plant enzyme demonstrated to promote susceptibility to oomycete pathogens. RNA interference assays that expressed double-stranded RNA complementary to Hs4F01 in transgenic Arabidopsis specifically decreased parasitic nematode Hs4F01 transcript levels and significantly reduced nematode infection levels. The combined data suggest that nematode secretion of an Hs4F01 annexin-like effector into host root cells may mimic plant annexin function during the parasitic interaction.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.