ArticleThe Journal of biological chemistry2010
General trends in trace element utilization revealed by comparative genomic analyses of Co, Cu, Mo, Ni, and Se.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 136 citations in OpenAlex.
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- Strong nickel enrichment co-located with redox-organic interactions in Neretva Vallis, Mars.Nature communications · 2026Article
- Increased Availability of Selective Trace Elements Enhanced Anaerobic Benzoate Oxidation inMicroorganisms · 2026Article
- The parasitic nematode Haemonchus contortus lacks molybdenum cofactor synthesis, leading to sulphite sensitivity and lethality in vitro.International journal for parasitology · 2025Article
- The curious case of selenium hyperaccumulation in Coelospermum decipiens from the Cape York Peninsula (Queensland, Australia).Annals of botany · 2024Article
- Selective trace elements significantly enhanced methane production in coal bed methane systems by stimulating microbial activity.Microbiology spectrum · 2024Article
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- The structural principles underlying molybdenum insertase complex assembly.Protein science : a publication of the Protein Society · 2023Article
- The elements of life: A biocentric tour of the periodic table.Advances in microbial physiology · 2023Article
- MTM1 displays a new function in the regulation of nickel resistance in Saccharomyces cerevisiae.Metallomics : integrated biometal science · 2022Article
- Selenium Metabolism and Selenoproteins in Prokaryotes: A Bioinformatics Perspective.Biomolecules · 2022Review
- The Role of the Nucleotides in the Insertion of the bis-Molybdopterin Guanine Dinucleotide Cofactor into apo-Molybdoenzymes.Molecules (Basel, Switzerland) · 2022Article
- Bioaccumulation of potentially toxic elements within the soil-plant system in Central Balkan region: analysis of the forest ecosystem capacity to mediate toxic elements.Environmental geochemistry and health · 2022Article
- Biogeographic and Evolutionary Patterns of Trace Element Utilization in Marine Microbial World.Genomics, proteomics & bioinformatics · 2021Article
- Hyperthermophilic methanogenic archaea act as high-pressure CHCommunications biology · 2021Article
- Bioinformatics of Selenoproteins.Antioxidants & redox signaling · 2020Review
- Bioinformatics of Metalloproteins and Metalloproteomes.Molecules (Basel, Switzerland) · 2020Review
- Comparative genomic analysis of selenium utilization traits in different marine environments.Journal of microbiology (Seoul, Korea) · 2020Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Trace elements are used by all organisms and provide proteins with unique coordination and catalytic and electron transfer properties. Although many trace element-containing proteins are well characterized, little is known about the general trends in trace element utilization. We carried out comparative genomic analyses of copper, molybdenum, nickel, cobalt (in the form of vitamin B(12)), and selenium (in the form of selenocysteine) in 747 sequenced organisms at the following levels: (i) transporters and transport-related proteins, (ii) cofactor biosynthesis traits, and (iii) trace element-dependent proteins. Few organisms were found to utilize all five trace elements, whereas many symbionts, parasites, and yeasts used only one or none of these elements. Investigation of metalloproteomes and selenoproteomes revealed examples of increased utilization of proteins that use copper in land plants, cobalt in Dehalococcoides and Dictyostelium, and selenium in fish and algae, whereas nematodes were found to have great diversity of copper transporters. These analyses also characterized trace element metabolism in common model organisms and suggested new model organisms for experimental studies of individual trace elements. Mismatches in the occurrence of user proteins and corresponding transport systems revealed deficiencies in our understanding of trace element biology. Biological interactions among some trace elements were observed; however, such links were limited, and trace elements generally had unique utilization patterns. Finally, environmental factors, such as oxygen requirement and habitat, correlated with the utilization of certain trace elements. These data provide insights into the general features of utilization and evolution of trace elements in the three domains of life.
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