ArticleActa biomaterialia2010
Changes in stiffness of resin-infiltrated demineralized dentin after remineralization by a bottom-up biomimetic approach.
Article in Acta biomaterialia, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Guidance on biomaterials for periodontal tissue regeneration: Fabrication methods, materials and biological considerations.Dental materials : official publication of the Academy of Dental Materials · 2025Review
- Nanoparticles Induced Biomimetic Remineralization of Acid-Etched Dentin.Journal of dentistry (Shiraz, Iran) · 2024Article
- Comparison of remineralization ability of tricalcium silicate and of glass ionomer cement on residual dentin: an in vitro study.BMC oral health · 2024Article
- Scale dependent nanomechanical properties of dentin adhesive and adhesive-collagen composite.Frontiers in dental medicine · 2024Article
- Remineralization of Dentinal Lesions Using Biomimetic Agents: A Systematic Review and Meta-Analysis.Biomimetics (Basel, Switzerland) · 2023Review
- Effect of polyhydroxy-terminated PAMAM dendrimer on dentin matrix metalloproteinases within the hybrid layers.BMC oral health · 2023Article
- Oxidized Dopamine Acrylamide Primer to Achieve Durable Resin-Dentin Bonding.Research (Washington, D.C.) · 2023Article
- Polyphenols Can Improve Resin-Dentin Bond Durability by Promoting Amorphous Calcium Phosphate Nanoparticles to Backfill the Dentin Matrix.International journal of nanomedicine · 2023Article
- Inhibition ofBioinorganic chemistry and applications · 2022Article
- Advances in biomineralization-inspired materials for hard tissue repair.International journal of oral science · 2021Review
- Effect of Remineralized Collagen on Dentin Bond Strength through Calcium Phosphate Ion Clusters or Metastable Calcium Phosphate Solution.Nanomaterials (Basel, Switzerland) · 2020Article
- The inhibitory effect of carboxyl-terminated polyamidoamine dendrimers on dentine host-derived matrix metalloproteinasesRoyal Society open science · 2019Article
- Dental remineralization via poly(amido amine) and restorative materials containing calcium phosphate nanoparticles.International journal of oral science · 2019Review
- Efficacy of Modified Bioactive Glass for Dentin Remineralization and Obstruction of Dentinal Tubules.Journal of dentistry (Tehran, Iran) · 2017Article
- Viscoelastic properties of collagen-adhesive composites under water-saturated and dry conditions.Journal of biomedical materials research. Part A · 2015Article
- Biomimetic remineralization of dentin.Dental materials : official publication of the Academy of Dental Materials · 2014Article
- Limitations in bonding to dentin and experimental strategies to prevent bond degradation.Journal of dental research · 2011Review
- Mechanical recovery of dentin following remineralization in vitro--an indentation study.Journal of biomechanics · 2011Article
- Biomimetic remineralization as a progressive dehydration mechanism of collagen matrices--implications in the aging of resin-dentin bonds.Acta biomaterialia · 2010Article
- In vitro remineralization of hybrid layers using biomimetic analogs.Journal of Zhejiang University. Science. BArticle
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
This study examined changes in elastic modulus, mineral density and ultrastructure of resin-infiltrated dentin after biomimetic remineralization. Sixty demineralized dentin beams were infiltrated with Clearfil Tri-S Bond, One-Step or Prime&Bond NT. They were immersed in simulated body fluid (SBF) for 1 week to maximize water sorption before determining the baseline elastic moduli. For each adhesive (N = 20) half of the beams remained immersed in SBF (control). The rest were immersed in a biomimetic remineralization medium. The elastic moduli were measured weekly for 15 additional weeks. Representative remineralized specimens were evaluated by X-ray microtomography and transmission electron microscopy (TEM). The elastic moduli of control resin-infiltrated dentin remained consistently low, while those immersed in the biomimetic remineralization medium increased by 55-118% after 4 months. X-ray microtomography of the remineralized specimens revealed decreases in mineral density from the beam surface to the beam core that were indicative of external mineral aggregation and internal mineral deposition. Interfibrillar and intrafibrillar remineralization of resin-sparse intertubular dentin were seen under TEM, together with remineralized peritubular dentin. Biomimetic remineralization occurs by diffusion of nanoprecursors and biomimetic analogs in completely demineralized resin-infiltrated dentin and proceeds without the contribution of materials released from a mineralized dentin base.
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Registered trials
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