ArticleActa biomaterialia2010
Small intestinal submucosa gel as a potential scaffolding material for cardiac tissue engineering.
Article in Acta biomaterialia, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 54 citations in OpenAlex.
- Extracellular Vesicles-in-Hydrogel (EViH) targeting pathophysiology for tissue repair.Bioactive materials · 2025Review
- The Current State of Extracellular Matrix Therapy for Ischemic Heart Disease.Medical sciences (Basel, Switzerland) · 2024Review
- Development potential of extracellular matrix hydrogels as hemostatic materials.Frontiers in bioengineering and biotechnology · 2023Review
- Changes in extracellular matrix in failing human non-ischemic and ischemic hearts with mechanical unloading.Journal of molecular and cellular cardiology · 2022Article
- Functional extracellular matrix hydrogel modified with MSC-derived small extracellular vesicles for chronic wound healing.Cell proliferation · 2022Article
- Biofabrication in Congenital Cardiac Surgery: A Plea from the Operating Theatre, Promise from Science.Micromachines · 2021Review
- Extracellular matrix hydrogel therapies: In vivo applications and development.Acta biomaterialia · 2018Review
- Reconstruction of abdominal wall musculofascial defects with small intestinal submucosa scaffolds seeded with tenocytes in rats.Tissue engineering. Part A · 2013Article
- Hydrogels derived from central nervous system extracellular matrix.Biomaterials · 2013Article
- Leveraging "raw materials" as building blocks and bioactive signals in regenerative medicine.Tissue engineering. Part B, Reviews · 2012Review
- Biomaterial applications in cardiovascular tissue repair and regeneration.Expert review of cardiovascular therapy · 2012Review
- Effects of small intestinal submucosa (SIS) on the murine innate immune microenvironment induced by heat-killed Staphylococcus aureus.PloS one · 2012Article
- Immune enhancement by novel vaccine adjuvants in autoimmune-prone NZB/W F1 mice: relative efficacy and safety.BMC immunology · 2011Article
- Biomaterials advances in patches for congenital heart defect repair.Journal of cardiovascular translational research · 2011Review
- Strategies for tissue engineering cardiac constructs to affect functional repair following myocardial infarction.Journal of cardiovascular translational research · 2011Review
- Extracellular matrix from porcine small intestinal submucosa (SIS) as immune adjuvants.PloS one · 2011Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Cardiac tissue engineering typically utilizes protein-rich scaffolding materials and growth factors to improve cardiac tissue function in vitro and in vivo. The objectives of this preliminary study were (i) to investigate the potential of porcine small intestinal submucosa gel (SIS gel) in cardiac tissue engineering and (ii) to compare the function of tissues based on either SIS gel or Matrigel, a tumor-derived benchmark material. Neonatal rat cardiac cells were combined with either SIS gel or Matrigel and cultured on porous elastomeric scaffolds composed of poly(glycerol sebacate) for 13days. Tissue function was assessed by measuring contraction rates twice daily. Tissue morphology was compared qualitatively by hematoxylin and eosin staining. Normalized troponin T expression (troponin T:DNA) was compared using image analysis. SIS gel constructs contracted at significantly higher rates than Matrigel constructs on days 8-11. Normalized troponin T expression was significantly higher in SIS gel constructs compared with Matrigel constructs. In summary, this research demonstrated that: (i) SIS gel can be used to create contractile engineered cardiac tissue; (ii) SIS gel produced engineered cardiac tissues with a more physiological contraction rate and higher phenotypic protein expression based on the basic in vitro examinations performed in this study.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.