ArticleComparative medicine2009
Infectious diseases in wild mice (Mus musculus) collected on and around the University of Pennsylvania (Philadelphia) Campus.
Article in Comparative medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
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- Gut microbiota and pathobiont exposure influences disease incidence in non-obese diabetic mice.Frontiers in microbiology · 2026Article
- Dominant effects of the immediate environment on the gut microbiome of mice used in biomedical research.mSystems · 2025Article
- Guidance on Establishing Health Monitoring Panels for Laboratory Mice to Reflect Contemporary Pathogen Prevalence.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Review
- Horizontal transmission of endemic viruses among rhesus macaques (Macaca mulatta): Implications for human cytomegalovirus vaccine/challenge design.Journal of medical primatology · 2023Article
- An Opportunistic Survey Reveals an Unexpected Coronavirus Diversity Hotspot in North America.Viruses · 2021Article
- Detection and quantification of house mouseInternational journal for parasitology. Parasites and wildlife · 2019Article
- Effects of Pelleting, Irradiation, and Autoclaving of Rodent Feed on MPV and MNV Infectivity.Journal of the American Association for Laboratory Animal Science : JAALAS · 2019Article
- Immune Relevant and Immune Deficient Mice: Options and Opportunities in Translational Research.ILAR journal · 2018Review
- Skin mites in mice (Mus musculus): high prevalence of Myobia sp. (Acari, Arachnida) in Robertsonian mice.Parasitology research · 2018Article
- Immune responses to the real world.Lab animal · 2017Article
- Modeling a Superorganism - Considerations Regarding the Use of "Dirty" Mice in Biomedical Research .The Yale journal of biology and medicine · 2017Review
- Marked seasonal variation in the wild mouse gut microbiota.The ISME journal · 2015Article
- The Complete Genome Sequence of the Murine Pathobiont Helicobacter typhlonius.Frontiers in microbiology · 2015Article
- Incidence rates of spontaneous disease in laboratory mice used at a large biomedical research institution.Journal of the American Association for Laboratory Animal Science : JAALAS · 2013Article
- Molecular detection of murine noroviruses in laboratory and wild mice.Veterinary microbiology · 2012Article
- High prevalence and species diversity of Helicobacter spp. detected in wild house mice.Applied and environmental microbiology · 2012Article
- Microbial and histopathologic considerations in the use of mouse models of inflammatory bowel diseases.Inflammatory bowel diseases · 2012Review
- Evaluation of pneumonia virus of mice as a possible human pathogen.Journal of virology · 2012Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Laboratory mice serve as important models in biomedical research. Monitoring these animals for infections and infestations and excluding causative agents requires extensive resources. Despite advancements in detection and exclusion over the last several years, these activities remain challenging for many institutions. The infections and infestations present in laboratory mouse colonies are well documented, but their mode of introduction is not always known. One possibility is that wild rodents living near vivaria somehow transmit infections to and between the colonies. This study was undertaken to determine what infectious agents the wild mice on the University of Pennsylvania (Philadelphia) campus were carrying. Wild mice were trapped and evaluated for parasites, viruses, and selected bacteria by using histopathology, serology, and PCR-based assays. Results were compared with known infectious agents historically circulating in the vivaria housing mice on campus and were generally different. Although the ectoparasitic burdens found on the 2 populations were similar, the wild mice had a much lower incidence of endoparasites (most notably pinworms). The seroprevalence of some viral infections was also different, with a low prevalence of mouse hepatitis virus among wild mice. Wild mice had a high prevalence of murine cytomegalovirus, an agent now thought to be confined to wild mouse populations. Helicobacter DNA was amplified from more than 90% of the wild mice (59% positive for H. hepaticus). Given the results of this study, we conclude that wild mice likely are not a source of infection for many of the agents that are detected in laboratory mouse colonies at the University of Pennsylvania.
Indexed as
Identifiers
19887025PMC2771607W1931949323What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.