ArticleThe Journal of experimental medicine1991
Lack of feedback inhibition of V kappa gene rearrangement by productively rearranged alleles.
Article in The Journal of experimental medicine, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 79 citations in OpenAlex.
- Skewed primary Igκ repertoire and V-J joining in C57BL/6 mice: implications for recombination accessibility and receptor editing.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Liver-expressed Igkappa superantigen induces tolerance of polyclonal B cells by clonal deletion not kappa to lambda receptor editing.The Journal of experimental medicine · 2011Article
- Receptor editing in self-reactive bone marrow B cells. The Journal of Experimental Medicine. 1993. 177: 1009-1020.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- B cell receptor editing in tolerance and autoimmunity.Annals of the New York Academy of Sciences · 2011Review
- Receptor selection in B and T lymphocytes.Annual review of immunology · 2000Review
- Restricted immunoglobulin variable region (Ig V) gene expression accompanies secondary rearrangements of light chain Ig V genes in mouse plasmacytomas.The Journal of experimental medicine · 1999Article
- A human immunoglobulin lambda locus is similarly well expressed in mice and humans.The Journal of experimental medicine · 1999Article
- Receptor editing occurs frequently during normal B cell development.The Journal of experimental medicine · 1998Article
- Self-antigen does not accelerate immature B cell apoptosis, but stimulates receptor editing as a consequence of developmental arrest.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Molecular mechanisms and selective influences that shape the kappa gene repertoire of IgM+ B cells.The Journal of clinical investigation · 1997Article
- Somatic diversification of antibody responses.Journal of clinical immunology · 1996Review
- Light chain replacement: a new model for antibody gene rearrangement.The Journal of experimental medicine · 1995Article
- Light chain editing in kappa-deficient animals: a potential mechanism of B cell tolerance.The Journal of experimental medicine · 1994Article
- Human lupus anti-DNA autoantibodies undergo essentially primary V kappa gene rearrangements.The EMBO journal · 1994Article
- Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections.The EMBO journal · 1993Article
- Immature surface Ig+ B cells can continue to rearrange kappa and lambda L chain gene loci.The Journal of experimental medicine · 1993Article
- Restricted kappa chain expression in early ontogeny: biased utilization of V kappa exons and preferential V kappa-J kappa recombinations.The Journal of experimental medicine · 1993Article
- Receptor editing: an approach by autoreactive B cells to escape tolerance.The Journal of experimental medicine · 1993Article
- Receptor editing in self-reactive bone marrow B cells.The Journal of experimental medicine · 1993Article
- B lymphocytes may escape tolerance by revising their antigen receptors.The Journal of experimental medicine · 1993Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Circular DNAs excised by immunoglobulin kappa chain gene rearrangements were cloned and characterized. 16 of 17 clones examined were double recombination products containing a V kappa-J kappa rearrangement (coding joint) as well as the reciprocal element (signal joint) of another V kappa-J kappa rearrangement. These products suggested multiple recombination, primary inversion, and secondary excision. In primary events, 5 of 16 translational reading frames were in-phase. Thus, V kappa gene rearrangement may not be inhibited by the presence of a productively rearranged allele. An unusually large trinucleotide (P) insertion forming a palindrome of 12 nucleotides was also observed in one of the coding joints.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.