Evidence map›Paper›PMID 19885376›Full record

ArticleParallel computing2008

RNAVLab: A virtual laboratory for studying RNA secondary structures based on grid computing technology.

Michela Taufer, Ming-Ying Leung, Thamar Solorio, Abel Licon, David Mireles, Roberto Araiza, Kyle L Johnson

Abstract read
In one paragraph

Article in Parallel computing, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Betanodavirus and VER Disease: A 30-year Research Review.Pathogens (Basel, Switzerland) · 2020
    Review
  2. Article
  3. Secondary Structure Predictions for Long RNA Sequences Based on Inversion Excursions and MapReduce.IEEE International Symposium on Parallel & Distributed Processing, Workshops and Phd Forum : [proceedings]. IEEE International Symposium on Parallel & Distributed Processing, Workshops and Phd Forum · 2013
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Michela TauferDepartment of Computer and Information Sciences, University of Delaware, Newark, DE 19716, United States.
Ming-Ying Leung
Thamar Solorio
Abel Licon
David Mireles
Roberto Araiza
Kyle L Johnson

Funding

TOXICOLOGY PROJECTG12RR008124 · NCRR · UNIVERSITY OF TEXAS EL PASO · PI WALSH, ELIZABETH J · 1992 to 2011
$20.8M
UTSA MBRS SCORE PROGRAMS06GM008194 · NIGMS · UNIVERSITY OF TEXAS SAN ANTONIO · PI TSIN, ANDREW T C · 1989 to 2006
$17.4M
UTEP SCORE InstrumentationS06GM008012 · NIGMS · UNIVERSITY OF TEXAS EL PASO · PI GARZA, KRISTINE M · 1989 to 2010
$15.8M
Undergraduate Biomedical Research Training at UTEPT34GM008048 · NIGMS · UNIVERSITY OF TEXAS EL PASO · PI PANNELL, KEITH H · 1985 to 2020
$9.2M
NCRR NIH HHS G12 RR008124NIGMS NIH HHS S06 GM008012NIGMS NIH HHS S06 GM008194NIGMS NIH HHS T34 GM008048
6 · The paper itself

Abstract

As ribonucleic acid (RNA) molecules play important roles in many biological processes including gene expression and regulation, their secondary structures have been the focus of many recent studies. Despite the computing power of supercomputers, computationally predicting secondary structures with thermodynamic methods is still not feasible when the RNA molecules have long nucleotide sequences and include complex motifs such as pseudoknots. This paper presents RNAVLab (RNA Virtual Laboratory), a virtual laboratory for studying RNA secondary structures including pseudoknots that allows scientists to address this challenge. Two important case studies show the versatility and functionalities of RNAVLab. The first study quantifies its capability to rebuild longer secondary structures from motifs found in systematically sampled nucleotide segments. The extensive sampling and predictions are made feasible in a short turnaround time because of the grid technology used. The second study shows how RNAVLab allows scientists to study the viral RNA genome replication mechanisms used by members of the virus family Nodaviridae.

Identifiers

PMID19885376
PMCPMC2714649

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.