ArticleThe Journal of experimental medicine1991
A novel class of anti-DNA antibodies identified in BALB/c mice.
Article in The Journal of experimental medicine, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 91 citations in OpenAlex.
- Peptide-based immunotherapy in lupus: Where are we now?Rheumatology and immunology research · 2023Review
- Amending HIV Drugs: A Novel Small-Molecule Approach To Target Lupus Anti-DNA Antibodies.Journal of medicinal chemistry · 2016Article
- Enhanced antibody responses to an HIV-1 membrane-proximal external region antigen in mice reconstituted with cultured lymphocytes.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Anti-DNA antibodies cross-react with C1q.Journal of autoimmunity · 2013Article
- NMDA Receptor Activity in Neuropsychiatric Disorders.Frontiers in psychiatry · 2013Article
- A model for lupus brain disease.Immunological reviews · 2012Review
- Generation of a unique small molecule peptidomimetic that neutralizes lupus autoantibody activity.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Lessons from an anti-DNA autoantibody.Molecular immunology · 2011Review
- Antigen is required for maturation and activation of pathogenic anti-DNA antibodies and systemic inflammation.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Development of self-reactive germinal center B cells and plasma cells in autoimmune Fc gammaRIIB-deficient mice.The Journal of experimental medicine · 2010Article
- Human lupus autoantibodies against NMDA receptors mediate cognitive impairment.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Electric charge and sugar chains of immunoglobulin G in systemic lupus erythematosus.Clinical and experimental nephrology · 2006Article
- The regulation and activation potential of autoreactive B cells.Immunologic research · 2003Review
- Estrogen up-regulates Bcl-2 and blocks tolerance induction of naive B cells.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Immunization with a peptide surrogate for double-stranded DNA (dsDNA) induces autoantibody production and renal immunoglobulin deposition.The Journal of experimental medicine · 1998Article
- Light chain usage in anti-double-stranded DNA B cell subsets: role in cell fate determination.The Journal of experimental medicine · 1997Article
- Peptide inhibition of glomerular deposition of an anti-DNA antibody.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Human autoantibody recognition of DNA.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Mutational analysis of an autoantibody: differential binding and pathogenicity.The Journal of experimental medicine · 1994Article
- Defining the genetic origins of three rheumatoid synovium-derived IgG rheumatoid factors.The Journal of clinical investigation · 1994Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
We have characterized four IgG monoclonal antibodies (mAbs) derived from BALB/c mice that bind double-stranded DNA (dsDNA) with high affinity. The hydridomas were selected for expression of a member of the VHS107 family. Three of the four cell lines use the VH11 gene and one uses the VH1 gene. These antibodies exhibit many characteristics of pathogenic anti-DNA antibodies. They are high affinity and not broadly crossreactive. Unlike the anti-DNA antibodies in autoimmune mice, they exhibit no somatic mutation in their VH genes. These results demonstrate that somatic mutation of VHS107 genes is not necessary for generating high affinity dsDNA binding. The fact that such antibodies have not previously been reported suggests that they are rare and that their expression may be downregulated in both nonautoimmune and autoimmune individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.