ArticleJournal of diabetes science and technology2008
Evaluation of the VIA Blood Chemistry Monitor for Glucose in Healthy and Diabetic Volunteers.
Article in Journal of diabetes science and technology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- An automated discontinuous venous blood sampling system for ex vivo glucose determination in humans.Journal of diabetes science and technology · 2009Trial
- Managing hyperglycemia during the COVID-19 pandemic: Improving outcomes using new technologies in intensive care.SAGE open medicine · 2020Review
- Glucose Management Technologies for the Critically Ill.Journal of diabetes science and technology · 2019Review
- Multicenter Observational Study of the First-Generation Intravenous Blood Glucose Monitoring System in Hospitalized Patients.Journal of diabetes science and technology · 2015Observational
- Vascular Glucose Sensor Symposium: Continuous Glucose Monitoring Systems (CGMS) for Hospitalized and Ambulatory Patients at Risk for Hyperglycemia, Hypoglycemia, and Glycemic Variability.Journal of diabetes science and technology · 2015Review
- Why Have So Many Intravascular Glucose Monitoring Devices Failed?Journal of diabetes science and technology · 2015Review
- Pilot evaluation of a prototype critical care blood glucose monitor in normal volunteers.Journal of diabetes science and technology · 2009Article
- Clinical need for continuous glucose monitoring in the hospital.Journal of diabetes science and technology · 2009Review
- An analysis: hyperglycemic intensive care patients need continuous glucose monitoring-easier said than done.Journal of diabetes science and technology · 2008Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundManual methods of blood glucose monitoring are labor-intensive, costly, prone to error, and expose the caregiver to blood. The VIA(R) blood chemistry monitor for glucose can automatically measure plasma glucose (PG) every 5 minutes for 72 hours using blood sampled from a peripheral vein/artery or a central vein.
methodsVIA performance was evaluated in eight normal and five type 1 diabetic (T1DM) subjects in 15 separate experiments. The VIA device was connected to a peripheral vein and reported a PG value every 5 minutes during each 510-minute experiment. Blood samples were collected manually every 10 minutes and assayed using a HemoCue(R) beta-glucose analyzer (HC). Whole blood HC measurements were corrected to PG values. Paired HC/VIA measurements (n = 717) were analyzed.
resultsMean PG was 90 +/- 14 and 96 +/- 12 mg/dl in normal subjects and 194 +/- 64 and 173 +/- 48 mg/dl in T1DM subject as measured by the HC and VIA, respectively. Clark error grid analysis revealed 86% points in zone A, 11% points in zone B, and 2% points in zone D. Linear regression analysis yielded the following equation: VIA = 0.732 x HC + 30.5 (r(2) = 0.954). Residual analysis revealed a glucose-dependent bias between the HC and the VIA. VIA data were transformed using the linear regression equation to correct for bias. After the correction, the mean absolute relative difference between the VIA and the HC was less than 10%, and 99.6% of data were in zones A and B. The VIA was able to sample blood automatically every 5 minutes for more than 8 hours in the laboratory setting. On average, the VIA reported glucose values for 94% of the samples it attempted to obtain.
conclusionsThis study demonstrated that the VIA blood chemistry monitor for glucose can reliably sample blood frequently for a prolonged period of time safely and effectively in diabetic and nondiabetic volunteers. Agreement between the two devices was the closest at normal glucose concentrations. After correcting for a glucose-dependent bias between the devices, the MARD was consistently less than 10% for all glucose ranges.
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