ArticleKorean journal of radiology
Gray matter concentration abnormality in brains of narcolepsy patients.
Article in Korean journal of radiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Gray Matter Alterations in Parkinson's Disease With Rapid Eye Movement Sleep Behavior Disorder: A Meta-Analysis of Voxel-Based Morphometry Studies.Frontiers in aging neuroscience · 2020Pooled it
- Article
- Neuroimaging findings in sleep disorders: A review article.Neurobiology of sleep and circadian rhythms · 2026Review
- Functional Brain Activity Alterations in Type 1 Narcolepsy Patients with Anxiety and Depression: A 7-Tesla Resting State-Functional Magnetic Resonance Imaging Study.Nature and science of sleep · 2025Article
- Assessing resting-state brain functional connectivity in adolescents and young adults with narcolepsy using functional near-infrared spectroscopy.Frontiers in human neuroscience · 2024Article
- Larger hypothalamic volume in narcolepsy type 1.Sleep · 2023Article
- Pediatric Narcolepsy-A Practical Review.Children (Basel, Switzerland) · 2022Review
- Hypothalamus and amygdala functional connectivity at rest in narcolepsy type 1.NeuroImage. Clinical · 2021Article
- A five-year longitudinal study reveals progressive cortical thinning in narcolepsy and faster cortical thinning in relation to early-onset.Brain imaging and behavior · 2020Article
- Beyond sleepy: structural and functional changes of the default-mode network in idiopathic hypersomnia.Sleep · 2019Article
- Instability of brain connectivity during nonrapid eye movement sleep reflects altered properties of information integration.Human brain mapping · 2019Article
- The neurobiological basis of narcolepsy.Nature reviews. Neuroscience · 2019Review
- The association of sleep and physical activity with integrity of white matter microstructure in bipolar disorder patients and healthy controls.Psychiatry research. Neuroimaging · 2017Article
- Topography of Slow Sigma Power during Sleep is Associated with Processing Speed in Preschool Children.Brain sciences · 2015Article
- Article
- Structural brain correlates of human sleep oscillations.NeuroImage · 2013Article
- Self-reported sleep correlates with prefrontal-amygdala functional connectivity and emotional functioning.Sleep · 2013Article
- Neuroimaging findings in narcolepsy with cataplexy.Current neurology and neuroscience reports · 2013Review
- Is High IQ Protective Against Cognitive Dysfunction in Narcoleptic Patients?Journal of clinical neurology (Seoul, Korea) · 2013Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate gray matter concentration changes in the brains of narcoleptic patients. MATERIALS AND
methodsTwenty-nine narcoleptic patient with cataplexy and 29 age and sex-matched normal subjects (mean age, 31 years old) underwent volumetric MRIs. The MRIs were spatially normalized to a standard T1 template and subdivided into gray matter, white matter, and cerebrospinal fluid (CSF). These segmented images were then smoothed using a 12-mm full width at half maximum (FWHM) isotropic Gaussian kernel. An optimized voxel-based morphometry protocol was used to analyze brain tissue concentrations using SPM2 (statistical parametric mapping). A one-way analysis of variance was applied to the concentration analysis of gray matter images.
resultsNarcoleptics with cataplexy showed reduced gray matter concentration in bilateral thalami, left gyrus rectus, bilateral frontopolar gyri, bilateral short insular gyri, bilateral superior frontal gyri, and right superior temporal and left inferior temporal gyri compared to normal subjects (uncorrected p < 0.001). Furthermore, small volume correction revealed gray matter concentration reduction in bilateral nuclei accumbens, hypothalami, and thalami (false discovery rate corrected p < 0.05).
conclusionGray matter concentration reductions were observed in brain regions related to excessive daytime sleepiness, cognition, attention, and memory in narcoleptics with cataplexy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.