ArticleJournal of diabetes science and technology2007
Fiber-coupled fluorescence affinity sensor for 3-day in vivo glucose sensing.
Article in Journal of diabetes science and technology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Blood glucose self-monitoring with a long-term subconjunctival glucose sensor.Journal of diabetes science and technology · 2013Trial
- First clinical evaluation of a new percutaneous optical fiber glucose sensor for continuous glucose monitoring in diabetes.Journal of diabetes science and technology · 2013Trial
- First clinical evaluation of a new long-term subconjunctival glucose sensor.Journal of diabetes science and technology · 2012Trial
- Polymer Optical Fiber Tip Mass Production Etch Mechanism to Achieve CPC Shape for Improved Biosensor Performance.Sensors (Basel, Switzerland) · 2019Article
- Prolonged Corrosion Stability of a Microchip Sensor Implant during In Vivo Exposure.Biosensors · 2018Article
- Polymer optical fiber compound parabolic concentrator tip for enhanced coupling efficiency for fluorescence based glucose sensors.Biomedical optics express · 2015Article
- A differential dielectric affinity glucose sensor.Lab on a chip · 2014Article
- Glucose Measurement by Affinity Sensor and Pulsed Measurements of Fluidic Resistances: Proof of Principle.Journal of diabetes science and technology · 2014Article
- Sensing glucose concentrations at GHz frequencies with a fully embedded Biomicro-electromechanical system (BioMEMS).Journal of applied physics · 2013Article
- A MEMS differential viscometric sensor for affinity glucose detection in continuous glucose monitoring.Journal of micromechanics and microengineering : structures, devices, and systems · 2013Article
- Acute in vivo performance evaluation of the fluorescence affinity sensor in the intravascular and interstitial space in Swine.Journal of diabetes science and technology · 2013Article
- A human pilot study of the fluorescence affinity sensor for continuous glucose monitoring in diabetes.Journal of diabetes science and technology · 2012Article
- Modulation of fibroblast inflammatory response by surface modification of a perfluorinated ionomer.Biointerphases · 2011Article
- Construction of a panel of glucose indicator proteins for continuous glucose monitoring.Biosensors & bioelectronics · 2011Article
- Preclinical in vivo study of a fluorescence affinity sensor for short-term continuous glucose monitoring in a small and large animal model.Diabetes technology & therapeutics · 2008Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundTo evaluate the feasibility of an implantable fiber-coupled fluorescence affinity sensor (FAS) for glucose monitoring in humans, we studied the acute and chronic in vivo performance in hairless rats and pigs.
methodsThe implantable fiber-coupled FAS was constructed by filling a dialysis chamber made of a regenerated cellulose membrane mounted to the distal tip of an optical fiber with fluorescent chemistry based on concanavalin A. Blood sugar changes in animals were induced by injections of insulin and dextrose. Determination of interstitial glucose concentrations in skin tissue was facilitated by measuring the fluorescence response of the FAS.
resultsThe acute in vivo response of the fiber-coupled FAS exhibited good correlation coefficients (>0.77) with blood sugar changes and minimal lag times (2-10 min) after 2 hours of sensor implantation. Equilibrium of the sensor signal with interstitial fluid was required less than 60 min after implantation. For both rats and pigs, chronic response of the FAS to blood sugar modulations measured during the third day of implantation successfully demonstrated proof-of-concept for short-term glucose monitoring. A slight decrease in sensitivity after 3 days in the small animal model was assumed to be caused by excessive mechanical forces on the implanted device because of high animal motility.
conclusionsOverall, the chronic in vivo performance of the FAS in two different animal models over 3 days was clinically acceptable and comparable to other continuous glucose monitoring platforms. The major benefit of the FAS is the absence of "autodestructive" side products and any device-related warm-up time after sensor reconnection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.