ArticleThe Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology2009
Role of T-type Ca Channels in the Spontaneous Phasic Contraction of Pregnant Rat Uterine Smooth Muscle.
Article in The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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14 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Utero-placental calcium and magnesium ion channels: A systematic review of obstetric implications of their alterations.Channels (Austin, Tex.) · 2026Pooled it
- Voltage-Gated Calcium Channels and the Parity-Dependent Differential Uterine Response to Oxytocin in Rats.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- Calcium signaling cascades differentially regulate PGFNaunyn-Schmiedeberg's archives of pharmacology · 2021Article
- Uterine contractions in rodent models and humans.Acta physiologica (Oxford, England) · 2021Review
- Trophoblasts Modulate the CaOxidative medicine and cellular longevity · 2021Article
- Beta-Estradiol Regulates Voltage-Gated Calcium Channels and Estrogen Receptors in Telocytes from Human Myometrium.International journal of molecular sciences · 2018Article
- Distinct roles of L- and T-type voltage-dependent Ca2+ channels in regulation of lymphatic vessel contractile activity.The Journal of physiology · 2014Article
- A molecular signature of tissues with pacemaker activity in the heart and upper urinary tract involves coexpressed hyperpolarization-activated cation and T-type Ca2+ channels.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- Computational modeling of inhibition of voltage-gated Ca channels: identification of different effects on uterine and cardiac action potentials.Frontiers in physiology · 2014Article
- Functional expression of T-type Ca2+ channels in spinal motoneurons of the adult turtle.PloS one · 2014Article
- Phasic contractions of the mouse vagina and cervix at different phases of the estrus cycle and during late pregnancy.PloS one · 2014Article
- Characterization of the tissue-level Ca2+ signals in spontaneously contracting human myometrium.Journal of cellular and molecular medicine · 2012Article
- TRPC1, STIM1, and ORAI influence signal-regulated intracellular and endoplasmic reticulum calcium dynamics in human myometrial cells.Biology of reproduction · 2011Article
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3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Although extracellular Ca(2+) entry through the voltage-dependent Ca(2+) channels plays an important role in the spontaneous phasic contractions of the pregnant rat myometrium, the role of the T-type Ca(2+) channels has yet to be fully identified. The aim of this study was to investigate the role of the T-type Ca(2+) channel in the spontaneous phasic contractions of the rat myometrium. Spontaneous phasic contractions and [Ca(2+)](i) were measured simultaneously in the longitudinal strips of female Sprague-Dawley rats late in their pregnancy (on day 18~20 of gestation: term=22 days). The expression of T-type Ca(2+) channel mRNAs or protein levels was measured. Cumulative addition of low concentrations (<1 microM) of nifedipine, a L-type Ca(2+) channel blocker, produced a decrease in the amplitude of the spontaneous Ca(2+) transients and contractions with no significant change in frequency. The mRNAs and proteins encoding two subunits (alpha1G, alpha1H) of the T-type Ca(2+) channels were expressed in longitudinal muscle layer of rat myometrium. Cumulative addition of mibefradil, NNC 55-0396 or nickel induced a concentration-dependent inhibition of the amplitude and frequency of the spontaneous Ca(2+) transients and contractions. Mibefradil, NNC 55-0396 or nickel also attenuated the slope of rising phase of spontaneous Ca(2+) transients consistent with the reduction of the frequency. It is concluded that T-type Ca(2+) channels are expressed in the pregnant rat myometrium and may play a key role for the regulation of the frequency of spontaneous phasic contractions.
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