ArticleThe Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology2009
Antifungal and Anticancer Activities of a Protein from the Mushroom Cordyceps militaris.
Article in The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 84 citations in OpenAlex.
- Ethanolic extract from fruiting bodies of Cordyceps militaris HL8 exhibits cytotoxic activities against cancer cells, skin pathogenic yeasts, and postharvest pathogen Penicillium digitatum.Archives of microbiology · 2024Article
- Metabolites and Their Bioactivities from the GenusMicroorganisms · 2022Review
- Review
- A review of the therapeutic and biological effects of edible and wild mushrooms.Bioengineered · 2021Review
- Molecular Cloning, Expression and Macrophage Activation of an Immunoregulatory Protein fromMolecules (Basel, Switzerland) · 2021Article
- Article
- Narrative Review: Bioactive Potential of Various Mushrooms as the Treasure of Versatile Therapeutic Natural Product.Journal of fungi (Basel, Switzerland) · 2021Review
- Antioxidant and Cytotoxic Effects and Identification ofFood technology and biotechnology · 2021Article
- Proteins fromPeerJ · 2020Article
- Article
- A novel protein from edible fungi Cordyceps militaris that induces apoptosis.Journal of food and drug analysis · 2018Article
- Anti-cancer effect of Cordyceps militaris in human colorectal carcinoma RKO cells via cell cycle arrest and mitochondrial apoptosis.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2015Article
- Pro-Apoptotic Activity of 4-Isopropyl-2-(1-Phenylethyl) Aniline Isolated from Cordyceps bassiana.Biomolecules & therapeutics · 2015Article
- Pharmacological and therapeutic potential of Cordyceps with special reference to Cordycepin.3 Biotech · 2014Article
- Bioactive proteins and peptides isolated from Chinese medicines with pharmaceutical potential.Chinese medicine · 2014Review
- Genome-wide transcriptome and proteome analysis on different developmental stages of Cordyceps militaris.PloS one · 2012Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mushroom Cordyceps militaris has been used for a long time in eastern Asia as a nutraceutical and in traditional Chinese medicine as a treatment for cancer patients. In the present study, a cytotoxic antifungal protease was purified from the dried fruiting bodies of C. militaris using anion-exchange chromatography on a DEAE-Sepharose column. Electrophoretic analyses indicated that this protein, designated C. militaris protein (CMP), has a molecular mass of 12 kDa and a pI of 5.1. The optimum conditions for protease activity were a temperature of 37 and pH of 7.0~9.0. The enzyme activity was specifically inhibited by the serine protease inhibitor phenylmethylsulfonyl fluoride. Amino acid composition of intact CMP and amino acid sequences of three major peptides from a tryptic digest of CMP were determined. CMP exerted strong antifungal effect against the growth of the fungus Fusarium oxysporum, and exhibited cytotoxicity against human breast and bladder cancer cells. These results indicate that C. militaris represents a source of a novel protein that might be applied in diverse biological and medicinal applications.
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