ArticleFuture neurology2009
Antidepressant-coincident mania in children and adolescents treated with selective serotonin reuptake inhibitors.
Article in Future neurology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 68 citations in OpenAlex.
- A randomized controlled trial of cognitive debiasing improves assessment and treatment selection for pediatric bipolar disorder.Journal of consulting and clinical psychology · 2016Trial
- Antidepressant treatment and risk of subsequent bipolar disorder in adolescents with unipolar depression.BMJ mental health · 2025Article
- Vortioxetine for Major Depressive Disorder in Children: 12-Week Randomized, Placebo-Controlled Study.JAACAP open · 2025Article
- A systematic review of selective serotonin reuptake inhibitor (SSRI)-induced activation and manic/hypomanic switch in children and adolescents.Scandinavian journal of child and adolescent psychiatry and psychology · 2025Review
- Pharmacogenetic Factors Influence Escitalopram Pharmacokinetics and Adverse Events in Youth with a Family History of Bipolar Disorder: A Preliminary Study.Journal of child and adolescent psychopharmacology · 2024Article
- A Double-Blind Randomized Trial to Investigate Mechanisms of Antidepressant-Related Dysfunctional Arousal in Depressed or Anxious Youth at Familial Risk for Bipolar Disorder.Journal of personalized medicine · 2022Article
- The Efficacy and Cognitive Effects of Acute Course Electroconvulsive Therapy Are Equal in Adolescents, Transitional Age Youth, and Young Adults.Journal of child and adolescent psychopharmacology · 2021Article
- Parsing cyclothymic disorder and other specified bipolar spectrum disorders in youth.Journal of affective disorders · 2018Article
- Treatment of psychiatric symptoms among offspring of parents with bipolar disorder.Current treatment options in psychiatry · 2017Article
- Comparing the CASI-4R and the PGBI-10 M for Differentiating Bipolar Spectrum Disorders from Other Outpatient Diagnoses in Youth.Journal of abnormal child psychology · 2017Article
- SSRIs-Related Behavioural Syndromes in Children and Adolescents.Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent · 2016Article
- Comparison of clinical characteristics of bipolar and depressive disorders in Korean clinical sample of youth: a retrospective chart review.European child & adolescent psychiatry · 2014Article
- Bipolar disorder in children.Psychiatry journal · 2014Review
- What goes up must come down: the burden of bipolar depression in youth.Journal of affective disorders · 2013Article
- Differentiating bipolar disorder-not otherwise specified and severe mood dysregulation.Journal of the American Academy of Child and Adolescent Psychiatry · 2013Review
- Bipolar depression in pediatric populations : epidemiology and management.Paediatric drugs · 2013Review
- Interventions for youth at high risk for bipolar disorder and schizophrenia.Child and adolescent psychiatric clinics of North America · 2012Review
- Generalizability of evidence-based assessment recommendations for pediatric bipolar disorder.Psychological assessment · 2012Article
- Antidepressants and psychostimulants in pediatric populations: is there an association with mania?Paediatric drugs · 2011Review
- Evidence-Based Strategies Improve Assessment of Pediatric Bipolar Disorder by Community Practitioners.Professional psychology, research and practice · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Several factors have amplified concern about the possibility that antidepressant medication may contribute to induction of pediatric mania. These include the high rate of antidepressant medication prescription, the recent surge in the rate of diagnosis of pediatric bipolar disorder in the USA, and a growing number of case reports and clinical studies showing coincidence of manic symptoms with antidepressant pharmacotherapy in both youths and adults. However, the question of how medications and manic symptoms might be related is complicated, and decisive research studies with rigorous designs for evaluating the issues have not been published. The situation makes it difficult for practitioners to make good, evidence-based decisions. The scientific literature is ambiguous, and the stakes are high. We review the extant literature, offer seven different conceptual models of how medication and mania might be related, and comment on the evidence and clinical implications of each.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.