ArticleJournal of the American Society of Hypertension : JASH
Pyk2 mediates increased adrenergic contractile responses in arteries from DOCA-salt mice - VASOACTIVE PEPTIDE SYMPOSIUM.
Article in Journal of the American Society of Hypertension : JASH. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- Angiotensin (1-7) Inhibits Ang II-mediated ERK1/2 Activation by Stimulating MKP-1 Activation in Vascular Smooth Muscle Cells.International journal of molecular and cellular medicine · 2020Article
- Regulation of gastric smooth muscle contraction via Ca2+-dependent and Ca2+-independent actin polymerization.PloS one · 2018Article
- A novel role of protein tyrosine kinase2 in mediating chloride secretion in human airway epithelial cells.PloS one · 2011Article
- O-GlcNAcylation contributes to augmented vascular reactivity induced by endothelin 1.Hypertension (Dallas, Tex. : 1979) · 2010Article
- Impaired vasodilator activity in deoxycorticosterone acetate-salt hypertension is associated with increased protein O-GlcNAcylation.Hypertension (Dallas, Tex. : 1979) · 2009Article
- Vascular Smooth Muscle Cell Signaling Mechanisms for Contraction to Angiotensin II and Endothelin-1.Journal of the American Society of Hypertension : JASHArticle
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Authors and funding
8 authors at 2 institutions in 2 countries.
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Abstract
backgroundThe calcium-dependent proline-rich tyrosine kinase (Pyk2), a nonreceptor protein activated by tyrosine phosphorylation, links G protein-coupled receptors to vascular responses. We tested the hypothesis that enhanced vascular reactivity in DOCA-salt hypertensive mice are due to increased activation of Pyk2. METHODS AND
resultsAorta and small mesenteric arteries from DOCA-salt and uninephrectomized (UNI) male C57Bl/6 mice were used. Systolic blood pressure (mmHg) was higher in DOCA (126+/-3) vs. UNI (100+/-4) mice. Vascular responses to phenylephrine (1nM to 100muM) were greater both in aorta and small mesenteric arteries from DOCA-salt than UNI, but treatment with Tyrphostin A-9 (0.1muM, Pyk2 inhibitor) abolished the difference among the groups. Pyk2 levels, as well as phospho-Pyk2(Tyr402), paxillin and phospho-paxillin(Tyr118) were increased in DOCA-salt aorta. Incubation of vessels with Tyrphostin A-9 restored phosphorylation of Pyk2 and paxillin.
conclusionIncreased activation of Pyk2 contributes to increased vascular contractile-responses in DOCA-salt mice.
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