ArticleJournal of the American Society of Hypertension : JASH2008
Murine and rat cavernosal responses to endothelin-1 and urotensin-II Vasoactive Peptide Symposium.
Article in Journal of the American Society of Hypertension : JASH, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 9 citations in OpenAlex.
- The effects of the urotensin-II receptor antagonist palosuran treatment on the corpora cavernosa of streptozotocin-induced diabetic rats.Asian journal of urology · 2025Article
- Pharmacological characterization of the relaxant effect induced by adrenomedullin in rat cavernosal smooth muscle.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2014Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundEndothelin-1 (ET-1) and urotensin-II (U-II) are the most potent constrictors of human vessels. Although the cavernosal tissue is higly responsive to ET-1, no information exists on the effects of U-II on cavernosal function. The aim of this study was to characterize ET-1 and U-II responses in corpora cavernosa from rats and mice. METHODS AND
resultsMale Wistar rats and C57/BL6 mice were used at 13 weeks. Cumulative concentration-response curves to ET-1, U-II and IRL-1620, an ET(B) agonist, were performed. ET-1 increased force generation in cavernosal strips from mice and rats, but no response to U-II was observed in the presence or absence of L-NAME, or in strips pre-stimulated with 20mM KCl. IRL-1620 did not induce cavernosal contraction even in presence of L-NAME, but induced a cavernosal relaxation which was greater in rats than mice. No relaxation responses to U-II were observed in cavernosal strips pre-contracted with phenylephrine. mRNA expression of ET-1, ET(A), ET(B) and U-II receptors, but not U-II was observed in cavernosal strips.
conclusionET-1, via ET(A) receptors activation, causes contractile responses in cavernosal strips from rats and mice whereas ET(B) receptor activation produces relaxation. Although the cavernosal tissue expresses U-II receptors, U-II does not induce contractile responses in corpora cavernosa from mice or rats.
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Registered trials
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