ArticleThe Journal of clinical investigation2009
The orphan nuclear receptor small heterodimer partner mediates male infertility induced by diethylstilbestrol in mice.
Article in The Journal of clinical investigation, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 56 citations in OpenAlex.
- Constitutive Androstane Receptor Regulates Germ Cell Homeostasis, Sperm Quality, and Male Fertility via Akt-Foxo1 Pathway.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Epigenetics and Testicular Cancer: Bridging the Gap Between Fundamental Biology and Patient Care.Frontiers in cell and developmental biology · 2022Review
- Multigenerational impacts of bile exposure are mediated by TGR5 signaling pathways.Scientific reports · 2018Article
- Crosstalk between BPA and FXRα Signaling Pathways Lead to Alterations of Undifferentiated Germ Cell Homeostasis and Male Fertility Disorders.Stem cell reports · 2018Article
- EB 2017 Article: Soy protein isolate feeding does not result in reproductive toxicity in the pre-pubertal rat testis.Experimental biology and medicine (Maywood, N.J.) · 2018Article
- The Bile Acid Nuclear Receptor FXRα Is a Critical Regulator of Mouse Germ Cell Fate.Stem cell reports · 2017Article
- Bile acid homeostasis controls CAR signaling pathways in mouse testis through FXRalpha.Scientific reports · 2017Article
- Nuclear receptors as pharmacological targets, where are we now?Cellular and molecular life sciences : CMLS · 2016Review
- Bile acid-FXRα pathways regulate male sexual maturation in mice.Oncotarget · 2016Article
- Nuclear receptors and endocrine disruptors in fetal and neonatal testes: a gapped landscape.Frontiers in endocrinology · 2015Review
- Article
- Effects of Low-Dose Diethylstilbestrol Exposure on DNA Methylation in Mouse Spermatocytes.PloS one · 2015Article
- Differential regulation of steroidogenic enzyme genes by TRα signaling in testicular Leydig cells.Molecular endocrinology (Baltimore, Md.) · 2014Article
- Transforming growth factor-β1 signaling represses testicular steroidogenesis through cross-talk with orphan nuclear receptor Nur77.PloS one · 2014Article
- Perinatal exposure to low-dose methoxychlor impairs testicular development in C57BL/6 mice.PloS one · 2014Article
- Spermatogenesis and cryptorchidism.Frontiers in endocrinology · 2014Review
- Exposure to bisphenol A disrupts meiotic progression during spermatogenesis in adult rats through estrogen-like activity.Cell death & disease · 2013Article
- Male fertility: Is spermiogenesis the critical step for answering biomedical issues?Spermatogenesis · 2013Article
- Diethylstilboestrol exposure does not reduce testosterone production in human fetal testis xenografts.PloS one · 2013Article
- Negative regulation of JAK2 by H3K9 methyltransferase G9a in leukemia.Molecular and cellular biology · 2012Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Studies in rodents have shown that male sexual function can be disrupted by fetal or neonatal administration of compounds that alter endocrine homeostasis, such as the synthetic nonsteroidal estrogen diethylstilbestrol (DES). Although the molecular basis for this effect remains unknown, estrogen receptors likely play a critical role in mediating DES-induced infertility. Recently, we showed that the orphan nuclear receptor small heterodimer partner (Nr0b2), which is both a target gene and a transcriptional repressor of estrogen receptors, controls testicular function by regulating germ cell entry into meiosis and testosterone synthesis. We therefore hypothesized that some of the harmful effects of DES on testes could be mediated through Nr0b2. Here, we present data demonstrating that Nr0b2 deficiency protected mice against the negative effects of DES on testis development and function. During postnatal development, Nr0b2-null mice were resistant to DES-mediated inhibition of germ cell differentiation, which may be the result of interference by Nr0b2 with retinoid signals that control meiosis. Adult Nr0b2-null male mice were also protected against the effects of DES; however, we suggest that this phenomenon was due to the removal of the repressive effects of Nr0b2 on steroidogenesis. Together, these data demonstrate that Nr0b2 plays a critical role in the pathophysiological changes induced by DES in the mouse testis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.