Evidence map›Paper›PMID 19884642›Full record

Trial reportNeurorehabilitation and neural repair

Effects of somatosensory stimulation on motor function after subacute stroke.

Adriana Bastos Conforto, Karina Nocelo Ferreiro, Camilla Tomasi, Renata Laurenti dos Santos, Viviane Loureiro Moreira, Suely Kazue Nagahashi Marie, Silvia Cristina Baltieri, Milberto Scaff, Leonardo G Cohen

Registry-linked trialAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neurorehabilitation and neural repair. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07091045 (Effectiveness of Robot-Assisted Structured Foot-Ankle Sensorimotor Training in Stroke Patients), which is not on this map. Cited by 65 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07091045 narecruitingnot on this map

Effectiveness of Robot-Assisted Structured Foot-Ankle Sensorimotor Training in Stroke Patients

TypeinterventionalSponsorMedipol UniversityRan2026 to 2027Enrolled30ConditionsStrokeArmsRobot-Assisted Foot-Ankle Training, Conventional Foot-Ankle Training
3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  10. Combined Brain and Peripheral Nerve Stimulation in Chronic Stroke Patients With Moderate to Severe Motor Impairment.Neuromodulation : journal of the International Neuromodulation Society · 2018
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5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Adriana Bastos ConfortoHospital das Clínicas/São Paulo University, São Paulo, Brazil, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil. abconf@yahoo.com
Karina Nocelo Ferreiro
Camilla Tomasi
Renata Laurenti dos Santos
Viviane Loureiro Moreira
Suely Kazue Nagahashi Marie
Silvia Cristina Baltieri
Milberto Scaff
Leonardo G Cohen

Funding

Modulating brain plasticity in rehabilitation of stroke and other brain lesionsZIANS003030 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI COHEN, LEONARDO GREGORIO · 2009 to 2025
$23.2M
Nerve Stimulation to Improve Hand Weakness in StrokeR21TW006706 · FIC · UNIVERSITY OF SAO PAULO · PI CONFORTO, ADRIANA B · 2004 to 2004
$81k
FIC NIH HHS 1 R21 TW006706FIC NIH HHS R21 TW006706Intramural NIH HHS
6 · The paper itself

Abstract

backgroundPrevious works showed potentially beneficial effects of a single session of peripheral nerve sensory stimulation (PSS) on motor function of a paretic hand in patients with subacute and chronic stroke.

objectiveTo investigate the influence of the use of different stimulus intensities over multiple sessions (repetitive PSS [RPSS]) paired with motor training.

methodsTo address this question, 22 patients were randomized within the second month after a single hemispheric stroke in a parallel design to application of 2-hour RPSS at 1 of 2 stimulus intensities immediately preceding motor training, 3 times a week, for 1 month. Jebsen-Taylor test (JTT, primary endpoint measure), pinch force, Functional Independence Measure (FIM), and corticomotor excitability to transcranial magnetic stimulation were measured before and after the end of the treatment month. JTT, FIM scores, and pinch force were reevaluated 2 to 3 months after the end of the treatment.

resultsBaseline motor function tests were comparable across the 2 RPSS intensity groups. JTT improved significantly in the lower intensity RPSS group but not in the higher intensity RPSS group at month 1. This difference between the 2 groups reduced by months 2 to 3.

conclusionsThese results indicate that multiple sessions of RPSS could facilitate training effects on motor function after subacute stroke depending on the intensity of stimulation. It is proposed that careful dose-response studies are needed to optimize parameters of RPSS stimulation before designing costly, larger, double-blind, multicenter clinical trials.

Indexed as

Motor ActivityStroke RehabilitationAcute DiseaseAdultAgedAged, 80 and overChronic DiseaseFemaleFunctional LateralityHandHumansMaleMedian NerveMiddle AgedMuscle, SkeletalParesis

Identifiers

PMID19884642
PMCPMC2824782

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.