Evidence map›Paper›PMID 19884363›Full record

ArticleAntimicrobial agents and chemotherapy2010

Biologic activities of the TolC-like protein of Neisseria meningitidis as assessed by functional complementation in Escherichia coli.

Nazia Kamal, William M Shafer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. A TolC-Like Protein ofFrontiers in microbiology · 2016
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Nazia KamalDepartment of Microbiology, Emory University School of Medicine, Atlanta, GA 30322, USA.
William M Shafer

Funding

GONOCOCCI: GENETICS OF RESISTANCE TO PMN PROTEINSR01AI021150 · NIAID · EMORY UNIVERSITY · PI SHAFER, WILLIAM MAURICE · 1985 to 2025
$5.5M
Gonococci: Genetics of Resistance to PMN ProteinsR37AI021150 · NIAID · EMORY UNIVERSITY · PI SHAFER, WILLIAM MAURICE · 2010 to 2019
$3.9M
Sexually Transmitted Infections &Antimicrobial PeptidesR01AI062755 · NIAID · EMORY UNIVERSITY · PI SHAFER, WILLIAM MAURICE · 2005 to 2009
$1.6M
NIAID NIH HHS AI 021150NIAID NIH HHS AI 062755NIAID NIH HHS R01 AI021150NIAID NIH HHS R01 AI062755NIAID NIH HHS R37 AI021150
6 · The paper itself

Abstract

Neisseria meningitidis can produce a TolC-like protein needed for secretion of FrpC but not efflux of antimicrobials. We now report that expression of the meningococcal tolC gene in a TolC-deficient strain of Escherichia coli can restore properties of alpha-hemolysis and antimicrobial resistance known to involve efflux pumps.

Indexed as

Anti-Bacterial AgentsBacterial ProteinsEscherichia coliEscherichia coli ProteinsGenetic Complementation TestHemolysin ProteinsHumansMicrobial Sensitivity TestsNeisseria meningitidisAnti-Bacterial AgentsBacterial ProteinsEscherichia coli ProteinsHemolysin ProteinsHlya protein, E coli

Identifiers

PMID19884363
PMCPMC2798496

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.