ArticleGenes & development2009
Elucidation of the transcription network governing mammalian sex determination by exploiting strain-specific susceptibility to sex reversal.
Article in Genes & development, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 68 citations in OpenAlex.
- GATA4 binding to the Sox9 enhancer mXYSRa/Enh13 is critical for testis differentiation in mouse.Communications biology · 2025Article
- Gonadal sex reversal at single-cell resolution in Znrf3-deficient mice.Development (Cambridge, England) · 2024Article
- Extraordinary variability in gene activation and repression programs during gonadal sex differentiation across vertebrates.Frontiers in cell and developmental biology · 2024Article
- Gene expression of male pathway genes sox9 and amh during early sex differentiation in a reptile departs from the classical amniote model.BMC genomics · 2023Article
- Transposable elements acquire time- and sex-specific transcriptional and epigenetic signatures along mouse fetal gonad development.Frontiers in cell and developmental biology · 2023Article
- Gonadal Sex Differentiation and Ovarian Organogenesis along the Cortical-Medullary Axis in Mammals.International journal of molecular sciences · 2022Review
- Improved biomarker discovery through a plot twist in transcriptomic data analysis.BMC biology · 2022Article
- Protection Against XY Gonadal Sex Reversal by a Variant Region on Mouse Chromosome 13.Genetics · 2020Article
- WOMEN IN REPRODUCTIVE SCIENCE: To be or not to be a testis.Reproduction (Cambridge, England) · 2019Review
- Male mice lacking ADAMTS-16 are fertile but exhibit testes of reduced weight.Scientific reports · 2019Article
- Testis Determination Requires a Specific FGFR2 Isoform to Repress FOXL2.Endocrinology · 2017Article
- Vertebrate sex determination: evolutionary plasticity of a fundamental switch.Nature reviews. Genetics · 2017Review
- Numb regulates somatic cell lineage commitment during early gonadogenesis in mice.Development (Cambridge, England) · 2017Article
- Genome-wide identification of regulatory elements in Sertoli cells.Development (Cambridge, England) · 2017Article
- Leveraging Online Resources to Prioritize Candidate Genes for Functional Analyses: Using the Fetal Testis as a Test Case.Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation · 2017Review
- Normal Levels of Sox9 Expression in the Developing Mouse Testis Depend on the TES/TESCO Enhancer, but This Does Not Act Alone.PLoS genetics · 2017Article
- Comparative analysis of a sex chromosome from the blackchin tilapia, Sarotherodon melanotheron.BMC genomics · 2016Article
- A recurrent p.Arg92Trp variant in steroidogenic factor-1 (NR5A1) can act as a molecular switch in human sex development.Human molecular genetics · 2016Article
- Ontogenic and morphological study of gonadal formation in genetically-modified sex reversal XY(POS) mice.The Journal of veterinary medical science · 2016Article
- Sry-Independent Overexpression of Sox9 Supports Spermatogenesis and Fertility in the Mouse.Biology of reproduction · 2015Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the identification of some key genes that regulate sex determination, most cases of disorders of sexual development remain unexplained. Evidence suggests that the sexual fate decision in the developing gonad depends on a complex network of interacting factors that converge on a critical threshold. To elucidate the transcriptional network underlying sex determination, we took the first expression quantitative trait loci (eQTL) approach in a developing organ. We identified reproducible differences in the transcriptome of the embryonic day 11.5 (E11.5) XY gonad between C57BL/6J (B6) and 129S1/SvImJ (129S1), indicating that the reported sensitivity of B6 to sex reversal is consistent with a higher expression of a female-like transcriptome in B6. Gene expression is highly variable in F2 XY gonads from B6 and 129S1 intercrosses, yet strong correlations emerged. We estimated the F2 coexpression network and predicted roles for genes of unknown function based on their connectivity and position within the network. A genetic analysis of the F2 population detected autosomal regions that control the expression of many sex-related genes, including Sry (sex-determining region of the Y chromosome) and Sox9 (Sry-box containing gene 9), the key regulators of male sex determination. Our results reveal the complex transcription architecture underlying sex determination, and provide a mechanism by which individuals may be sensitized for sex reversal.
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