ArticlePhilosophical transactions. Series A, Mathematical, physical, and engineering sciences2009
A multiformalism and multiresolution modelling environment: application to the cardiovascular system and its regulation.
Article in Philosophical transactions. Series A, Mathematical, physical, and engineering sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Mathematical modelling of the influence ofHeliyon · 2024Article
- Thoroughly Calibrated Modular Agent-Based Model of the Human Cardiovascular and Renal Systems for Blood Pressure Regulation in Health and Disease.Frontiers in physiology · 2021Article
- A model-based approach for the evaluation of vagal and sympathetic activities in a newborn lamb.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2013Article
- Multiobjective patient-specific estimation of a coronary circulation model for triple vessel disease.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2013Article
- Regulation of cell behavior and tissue patterning by bioelectrical signals: challenges and opportunities for biomedical engineering.Annual review of biomedical engineering · 2012Review
- Virtual patients and sensitivity analysis of the Guyton model of blood pressure regulation: towards individualized models of whole-body physiology.PLoS computational biology · 2012Article
- Embedding a cardiac pulsatile model into an integrated model of the cardiovascular regulation for heart failure followup.IEEE transactions on bio-medical engineering · 2011Article
- Tuneable resolution as a systems biology approach for multi-scale, multi-compartment computational models.Wiley interdisciplinary reviews. Systems biology and medicineReview
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The role of modelling and simulation in the systemic analysis of living systems is now clearly established. Emerging disciplines, such as systems biology, and worldwide research actions, such as the Physiome Project or the Virtual Physiological Human, are based on an intensive use of modelling and simulation methodologies and tools. One of the key aspects in this context is to perform an efficient integration of various models representing different biological or physiological functions, at different resolutions, spanning through different scales. This paper presents a multiformalism modelling and simulation environment (M2SL) that has been conceived to ease model integration. A given model is represented as a set of coupled and atomic model components that may be based on different mathematical formalisms with heterogeneous structural and dynamical properties. A co-simulation approach is used to solve these hybrid systems. The pioneering model of the overall regulation of the cardiovascular system proposed by Guyton and co-workers in 1972 has been implemented under M2SL and a pulsatile ventricular model based on a time-varying elastance has been integrated in a multi-resolution approach. Simulations reproducing physiological conditions and using different coupling methods show the benefits of the proposed environment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.