ArticleBiophysical journal2009
Simulation of spontaneous Ca2+ oscillations in astrocytes mediated by voltage-gated calcium channels.
Article in Biophysical journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 65 citations in OpenAlex.
- Functional Expression of Nicotinic Receptors on iPSC-Derived Astrocytes and Signalling Disturbances by a Panel of Neonicotinoid Pesticides and Their Metabolites.International journal of molecular sciences · 2026Article
- Mechanisms underlying spontaneous and evoked calcium responses in oligodendrocyte precursor cells: A modeling investigation.PLoS computational biology · 2026Article
- Numerical Simulations and Bifurcation of CaCell biochemistry and biophysics · 2025Article
- Analog neuromorphic circuit for spontaneous CaScientific reports · 2023Article
- High-affinity P2Y2 and low-affinity P2X7 receptor interaction modulates ATP-mediated calcium signaling in murine osteoblasts.PLoS computational biology · 2021Article
- Unraveling Aβ-Mediated Multi-Pathway Calcium Dynamics in Astrocytes: Implications for Alzheimer's Disease Treatment From Simulations.Frontiers in physiology · 2021Article
- A Neuron-Glial Model of Exosomal Release in the Onset and Progression of Alzheimer's Disease.Frontiers in computational neuroscience · 2021Article
- Bioengineering functional smooth muscle with spontaneous rhythmic contraction in vitro.Scientific reports · 2018Article
- Biological Oscillators in Nanonetworks-Opportunities and Challenges.Sensors (Basel, Switzerland) · 2018Review
- Computational Models for Calcium-Mediated Astrocyte Functions.Frontiers in computational neuroscience · 2018Review
- Granule cell excitability regulates gamma and beta oscillations in a model of the olfactory bulb dendrodendritic microcircuit.Journal of neurophysiology · 2016Article
- Article
- Quantifying the uncertainty of spontaneous Ca2+ oscillations in astrocytes: particulars of Alzheimer's disease.Biophysical journal · 2011Article
- Calcium oscillations.Cold Spring Harbor perspectives in biology · 2011Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this computational study was to investigate the possible role of voltage-gated Ca(2+) channels in spontaneous Ca(2+) oscillations of astrocytes. By incorporating different types of voltage-gated Ca(2+) channels and a previous model, this study reproduced typical Ca(2+) oscillations in silico. Our model could mimic the oscillatory phenomenon under a wide range of experimental conditions, including resting membrane potential (-75 to -60 mV), extracellular Ca(2+) concentration (0.1 to 1500 muM), temperature (20 to 37 degrees C), and blocking specific Ca(2+) channels. By varying the experimental conditions, the amplitude and duration of Ca(2+) oscillations changed slightly (both <25%), while the frequency changed significantly ( approximately 400%). This indicates that spontaneous Ca(2+) oscillations in astrocytes might be an all-or-none process, which might be frequency-encoded in signaling. Moreover, the properties of Ca(2+) oscillations were found to be related to the dynamics of Ca(2+) influx, and not only to a constant influx. Therefore, calcium channels dynamics should be used in studying Ca(2+) oscillations. This work provides a platform to explore the still unclear mechanism of spontaneous Ca(2+) oscillations in astrocytes.
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