ArticleBiophysical journal2009
Mathematical model of the Drosophila circadian clock: loop regulation and transcriptional integration.
Article in Biophysical journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Upstream open reading frames dynamically modulate CLOCK protein translation to regulate circadian rhythms and sleep.PLoS biology · 2025Article
- Stable Expression of dmiR-283 in the Brain Promises Positive Effects in Endurance Exercise on Sleep-Wake Behavior in AgingInternational journal of molecular sciences · 2023Article
- Long-range connections are crucial for synchronization transition in a computational model of Drosophila brain dynamics.Scientific reports · 2022Article
- Mathematical Modeling in Circadian Rhythmicity.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Collective Dynamics of Neural Networks With Sleep-Related Biological Drives in Drosophila.Frontiers in computational neuroscience · 2021Article
- Article
- Heat the Clock: Entrainment and Compensation inJournal of circadian rhythms · 2019Article
- Approximate kernel reconstruction for time-varying networks.BioData mining · 2019Article
- Modelling with ANIMO: between fuzzy logic and differential equations.BMC systems biology · 2016Article
- Clk post-transcriptional control denoises circadian transcription both temporally and spatially.Nature communications · 2015Article
- Tracking of time-varying genomic regulatory networks with a LASSO-Kalman smoother.EURASIP journal on bioinformatics & systems biology · 2014Article
- Inverse perturbation for optimal intervention in gene regulatory networks.Bioinformatics (Oxford, England) · 2011Article
- Dynamics of the Drosophila circadian clock: theoretical anti-jitter network and controlled chaos.PloS one · 2010Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Eukaryotic circadian clocks include interconnected positive and negative feedback loops. The clock-cycle dimer (CLK-CYC) and its homolog, CLK-BMAL1, are key transcriptional activators of central components of the Drosophila and mammalian circadian networks, respectively. In Drosophila, negative loops include period-timeless and vrille; positive loops include par domain protein 1. Clockwork orange (CWO) is a recently discovered negative transcription factor with unusual effects on period, timeless, vrille, and par domain protein 1. To understand the actions of this protein, we introduced a new system of ordinary differential equations to model regulatory networks. The model is faithful in the sense that it replicates biological observations. CWO loop actions elevate CLK-CYC; the transcription of direct targets responds by integrating opposing signals from CWO and CLK-CYC. Loop regulation and integration of opposite transcriptional signals appear to be central mechanisms as they also explain paradoxical effects of period gain-of-function and null mutations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.