ArticleBiophysical journal2009
A cAMP signaling model explains the benefit of maintaining two forms of phosphodiesterase in Dictyostelium.
Article in Biophysical journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed.
- Dynamic cluster field modeling of collective chemotaxis.Scientific reports · 2024Article
- A counter-enzyme complex regulates glutamate metabolism in Bacillus subtilis.Nature chemical biology · 2022Article
- Cell dispersal by localized degradation of a chemoattractant.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Fold-change detection and scale invariance of cell-cell signaling in social amoeba.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Collective Signal Processing in Cluster Chemotaxis: Roles of Adaptation, Amplification, and Co-attraction in Collective Guidance.PLoS computational biology · 2016Article
- Yeast mating and image-based quantification of spatial pattern formation.PLoS computational biology · 2014Article
- Analysis of phenotypic evolution in Dictyostelia highlights developmental plasticity as a likely consequence of colonial multicellularity.Proceedings. Biological sciences · 2013Article
- Robustness of self-organizing chemoattractant field arising from precise pulse induction of its breakdown enzyme: a single-cell level analysis of PDE expression in Dictyostelium.Biophysical journal · 2013Article
- Evolution of self-organisation in Dictyostelia by adaptation of a non-selective phosphodiesterase and a matrix component for regulated cAMP degradation.Development (Cambridge, England) · 2012Article
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Abstract
Starving Dictyostelium cells respond chemotactically to cell-generated waves of cyclic adenosine -3',5'- monophosphate (cAMP) that guide cell aggregation toward a signaling center. In this process, a large number of cells are recruited, resulting in the formation of aggregation territories that are essential for fruiting body formation. The enzyme PdsA phosphodiesterase (PDE), a crucial component of the signaling system, breaks down the external cAMP and can be either membrane-bound or secreted. The existence of two such forms is unusual in cell biology, and it remains to be determined why they have both been maintained through evolution. Here, using a model of the cAMP signaling system, I show that colonies can successfully organize into aggregates over a wider range of initial cell densities when both forms of PDE are present in an appropriately tuned ratio than when only a single form is present. The model indicates that membrane-bound PDE maintains aggregation-territory integrity in colonies with high initial cell density, whereas the secreted form is important for wave propagation at low cell densities. Thus, the ultimate retention of both forms can increase territory size. These findings have implications for other excitable media, including Ca(2+) propagation in cardiac cells and propagation of electrical excitation in nerve axons, since these systems have similar features of spatial nonuniform "release" and "degradation" of the relevant signals.
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