Evidence map›Paper›PMID 19883159›Full record

ArticleScandinavian journal of infectious diseases2010

Comparison of clinical features and immunological parameters of patients with dehydrating diarrhoea infected with Inaba or Ogawa serotypes of Vibrio cholerae O1.

Ashraful I Khan, Fahima Chowdhury, Jason B Harris, Regina C Larocque, Abu S G Faruque, Edward T Ryan, Stephen B Calderwood, Firdausi Qadri

Open access · greenAbstract readComparative Study
In one paragraph

Article in Scandinavian journal of infectious diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. bioRxiv : the preprint server for biology · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. Dissecting serotype-specific contributions to live oral cholera vaccine efficacy.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. The increased severity in patients presenting to hospital with diarrhea in Dhaka, Bangladesh since the emergence of the hybrid strain of Vibrio cholerae O1 is not unique to cholera patients.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2015
    Article
  14. Article
  15. Article
  16. Phage Types ofJournal of global infectious diseases
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Ashraful I KhanLaboratory Sciences Division, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Fahima Chowdhury
Jason B Harris
Regina C Larocque
Abu S G Faruque
Edward T Ryan
Stephen B Calderwood
Firdausi Qadri
Harvard University · USInternational Centre for Diarrhoeal Disease Research · BD

Funding

Fogarty International Clinical Research Scholars Support Center @ Vanderbilt-AAMCR24TW007988 · FIC · VANDERBILT UNIVERSITY · PI VERMUND, STEN H. · 2007 to 2011
$27.6M
Protecutive immunity to human cholera in BangladeshU01AI058935 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI CALDERWOOD, STEPHEN B., RYAN, EDWARD T. · 2003 to 2014
$7.8M
Training program in vaccine development and public healthD43TW005572 · FIC · MASSACHUSETTS GENERAL HOSPITAL · PI QADRI, FIRDAUSI, RYAN, EDWARD T. · 2000 to 2025
$5.4M
Mucosal Immunity to Antigens Expressed by V.choleraeR01AI040725 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI RYAN, EDWARD T. · 1997 to 2006
$2.5M
The role of TcpA in cholera immunity and vaccinationK01TW007409 · FIC · MASSACHUSETTS GENERAL HOSPITAL · PI HARRIS, JASON B · 2005 to 2011
$867k
Identification of human gene polymorphisms related to Vibrio cholerae infectionK01TW007144 · FIC · MASSACHUSETTS GENERAL HOSPITAL · PI LAROCQUE, REGINA C · 2004 to 2009
$617k
FIC NIH HHS D43 TW005572FIC NIH HHS D43 TW05572FIC NIH HHS K01 TW007144FIC NIH HHS K01 TW007409FIC NIH HHS R24 TW007988NIAID NIH HHS AI40725NIAID NIH HHS R01 AI040725NIAID NIH HHS U01 AI058935
6 · The paper itself

Abstract

Vibrio cholerae O1, Ogawa and Inaba serotypes, both cause severe cholera. We compared clinical and immunological features in patients in Bangladesh infected with these 2 serotypes. Blood was collected from hospitalized Ogawa (N=146) or Inaba (N=191) patients at the acute stage (day 2) and 5 and 19 days later. Ogawa patients were younger than Inaba, presented with shorter duration of diarrhoea, and had more frequent abdominal pain, vomiting and need for intravenous fluids (p<0.05). Inaba patients more frequently had dark-field positive stools (p<0.01). Inaba strains were more susceptible to tetracycline and erythromycin than Ogawa strains (p<0.001). Ogawa infection produced higher plasma vibriocidal as well as IgG responses to cholera toxin B subunit, toxin-coregulated pilus subunit and lipopolysaccharide (LPS); higher IgA responses to LPS in 'antibody in lymphocyte supernatant' (ALS) specimens were also seen. These results suggest that a cholera vaccine based on the Ogawa serotype needs to be further investigated.

Indexed as

AdolescentAdultAgedAged, 80 and overAnti-Bacterial AgentsAntibodies, BacterialBangladeshChildChild, PreschoolCholeraCholera ToxinDehydrationErythromycinFecesFemaleHumansAnti-Bacterial AgentsAntibodies, BacterialCholera ToxinErythromycinImmunoglobulin GLipopolysaccharidesTetracycline

Identifiers

PMID19883159
PMCPMC3786431
OpenAlexW2097584324

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.