ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2009
Cyclic Nrarp mRNA expression is regulated by the somitic oscillator but Nrarp protein levels do not oscillate.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- The vertebrate Embryo Clock: Common players dancing to a different beat.Frontiers in cell and developmental biology · 2022Review
- From the primitive streak to the somitic mesoderm: labeling the early stages of chick embryos using EGFP transfection.Anatomical science international · 2018Article
- Comparison between Timelines of Transcriptional Regulation in Mammals, Birds, and Teleost Fish Somitogenesis.PloS one · 2016Article
- Timing embryo segmentation: dynamics and regulatory mechanisms of the vertebrate segmentation clock.BioMed research international · 2014Review
- Transcript processing and export kinetics are rate-limiting steps in expressing vertebrate segmentation clock genes.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- The Notch-regulated ankyrin repeat protein is required for proper anterior-posterior somite patterning in mice.Genesis (New York, N.Y. : 2000) · 2012Article
- The period of the somite segmentation clock is sensitive to Notch activity.Molecular biology of the cell · 2011Article
- The Wnt3a/β-catenin target gene Mesogenin1 controls the segmentation clock by activating a Notch signalling program.Nature communications · 2011Article
- Evolutionary plasticity of segmentation clock networks.Development (Cambridge, England) · 2011Article
- Review
- The segmentation clock mechanism moves up a notch.Trends in cell biology · 2010Review
- The chick somitogenesis oscillator is arrested before all paraxial mesoderm is segmented into somites.BMC developmental biology · 2010Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 3 countries.
Funding
Abstract
Somites are formed progressively from the presomitic mesoderm (PSM) in a highly regulated process according to a strict periodicity driven by an oscillatory mechanism. The Notch and Wnt pathways are key components in the regulation of this somitic oscillator and data from Xenopus and zebrafish embryos indicate that the Notch-downstream target Nrarp participates in the regulation of both activities. We have analyzed Nrarp/nrarp-a expression in the PSM of chick, mouse and zebrafish embryos, and we show that it cycles in synchrony with other Notch regulated cyclic genes. In the mouse its transcription is both Wnt- and Notch-dependent, whereas in the chick and fish embryo it is simply Notch-dependent. Despite oscillating mRNA levels, Nrarp protein does not oscillate in the PSM. Finally, neither gain nor loss of Nrarp function interferes with the normal expression of Notch-related cyclic genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.