ArticleSurgery today2009
Pouchitis disease activity index (PDAI) does not predict patients with symptoms of pouchitis who will respond to antibiotics.
Article in Surgery today, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Disease Activity Indices for Pouchitis: A Systematic Review.Inflammatory bowel diseases · 2022Pooled it
- Diagnosis and Medical Treatment of Acute and Chronic Idiopathic Pouchitis in Inflammatory Bowel Disease.Medicina (Kaunas, Lithuania) · 2024Review
- Pouchitis: insight into the pathogenesis and clinical aspects.American journal of translational research · 2022Review
- Clinical features and management of pouchitis in Japanese ulcerative colitis patients.Surgery today · 2013Article
- The diameter of the ileal J-pouch-anal anastomosis as an important risk factor of pouchitis - clinical observations.Medical science monitor : international medical journal of experimental and clinical research · 2011Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate whether the pouchitis disease activity index (PDAI) alone is sufficient to select appropriate treatment plans for ulcerative colitis patients with bowel movement problems following ileal pouch-anal anastomosis (IPAA).
methodsThe study included 70 patients undergoing an IPAA. For these patients, an evaluation by PDAI was performed prospectively at 1-2 years after the ileostomy closure. When the symptoms relevant to bowel movement appeared, PDAI was evaluated and metronidazole or ciprofloxacin was administered. Pouchitis was diagnosed in patients with PDAI scores of 7 or higher. The patients whose PDAI score was less than 7 and who responded to antibiotic therapy were defined as treatment responders having disease not diagnosed by PDAI (TR-NDPDAI).
resultsPouchitis was diagnosed in 16 of the 70 enrolled patients (22.9%) using the PDAI scoring system. Of these 16 patients, 11 had acute pouchitis and 5 had chronic pouchitis. Twenty-one patients whose PDAI score was less than 7 were symptomatic. Among them, 12 were TR-NDPDAI. In patients with TR-NDPDAI, antibiotic treatment resulted in significant improvements in the PDAI score (P < 0.001) and in clinical symptoms (P < 0.001) after treatment.
conclusionAntibiotic treatment was effective in a considerable number of ulcerative colitis patients whose PDAI score was less than 7 after IPAA.
Indexed as
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Registered trials
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