ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2010
Bifidobacterium longum HY8004 attenuates TNBS-induced colitis by inhibiting lipid peroxidation in mice.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 34 citations in OpenAlex.
- Comparison of Selenium-EnrichedNutrients · 2022Article
- Alleviation effects of Bifidobacterium breve on DSS-induced colitis depends on intestinal tract barrier maintenance and gut microbiota modulation.European journal of nutrition · 2021Article
- Evaluation of the Effects of DifferentJournal of immunology research · 2021Article
- Protective Effects of Bifidobacterial Strains Against ToxigenicFrontiers in microbiology · 2018Article
- Protective effect of Laminaria japonica with probiotics on murine colitis.Mediators of inflammation · 2014Article
- Expression of catalase in Lactobacillus fermentum and evaluation of its anti-oxidative properties in a dextran sodium sulfate induced mouse colitis model.World journal of microbiology & biotechnology · 2013Article
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Authors and funding
7 authors at 2 institutions in 1 country.
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Abstract
objectiveTo investigate the mechanisms of the preventive activity of lactic acid bacteria in colitis, the inhibitory effect of Bifidobacterium longum HY8004, which potently inhibited lipid peroxidation in vitro, was examined in 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitic mice.
methodsWe measured the ability of lactic acid bacteria (LAB) to inhibit lipid peroxidation in vitro and to inhibit colitis outcomes, colon shortening, and myeloperoxidase activity in TNBS-induced colitis in C3H/HeN and C3H/HeJ mice. We also measured levels of the inflammatory markers interleukin (IL)-1 beta and tumor necrosis factor (TNF)-alpha and their transcription factor, NF-kappaB, in the colon by enzyme-linked immunosorbent assay and immunoblot analysis.
resultsAmong the LAB tested, B. logum HY8004 most potently inhibited lipid peroxidation in vitro but did not inhibit TLR-4-linked NF-kappaB activation in HEK cells. Oral administration of HY8004 inhibited TNBS-induced colon shortening and myeloperoxidase activity in the colon of C3H/HeN and C3H/HeJ mice as well as IL-1 beta and TNF-alpha expression. B. longum HY8004 also inhibited TNBS-induced lipid peroxidation, TLR-4 expression, and NF-kappaB activation in the colon of C3H/HeN and C3H/HeJ mice.
conclusionB. longum HY8004 can improve colitis via the inhibition of lipid peroxidation as well as NF-kappaB activation.
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