ArticleCurrent genomics2009
Regulation of interactions with sliding clamps during DNA replication and repair.
Article in Current genomics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- The B. subtilis replicative polymerases bind the sliding clamp with different strengths to tune their activity in DNA replication.Nucleic acids research · 2025Article
- MutS functions as a clamp loader by positioning MutL on the DNA during mismatch repair.Nature communications · 2022Article
- The RecD2 helicase balances RecA activities.Nucleic acids research · 2022Article
- The methylation-independent mismatch repair machinery inMicrobiology (Reading, England) · 2021Review
- Bacteriophage Twort protein Gp168 is a β-clamp inhibitor by occupying the DNA sliding channel.Nucleic acids research · 2021Article
- DNA Damage Response and Immune Defense.International journal of molecular sciences · 2020Review
- Watching DNA Replication Inhibitors in Action: Exploiting Time-Lapse Microfluidic Microscopy as a Tool for Target-Drug Interaction Studies inAntimicrobial agents and chemotherapy · 2019Article
- Disentangling polydispersity in the PCNA-p15PAF complex, a disordered, transient and multivalent macromolecular assembly.Nucleic acids research · 2017Article
- MutS regulates access of the error-prone DNA polymerase Pol IV to replication sites: a novel mechanism for maintaining replication fidelity.Nucleic acids research · 2016Article
- Transposase interaction with the β sliding clamp: effects on insertion sequence proliferation and transposition rate.Scientific reports · 2015Article
- Slow unloading leads to DNA-bound β2-sliding clamp accumulation in live Escherichia coli cells.Nature communications · 2014Article
- Chromosomal replication dynamics and interaction with the β sliding clamp determine orientation of bacterial transposable elements.Genome biology and evolution · 2014Article
- Replication slippage of the thermophilic DNA polymerases B and D from the Euryarchaeota Pyrococcus abyssi.Frontiers in microbiology · 2014Article
- Phosphoinositide 3-kinase beta controls replication factor C assembly and function.Nucleic acids research · 2013Article
- ATM protein physically and functionally interacts with proliferating cell nuclear antigen to regulate DNA synthesis.The Journal of biological chemistry · 2012Article
- DNA mismatch repair system: repercussions in cellular homeostasis and relationship with aging.Oxidative medicine and cellular longevity · 2012Review
- The C-terminal domain of the bacterial SSB protein acts as a DNA maintenance hub at active chromosome replication forks.PLoS genetics · 2010Article
- Article
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The molecular machines that replicate the genome consist of many interacting components. Essential to the organization of the replication machinery are ring-shaped proteins, like PCNA (Proliferating Cell Nuclear Antigen) or the beta- clamp, collectively named sliding clamps. They encircle the DNA molecule and slide on it freely and bidirectionally. Sliding clamps are typically associated to DNA polymerases and provide these enzymes with the processivity required to synthesize large chromosomes. Additionally, they interact with a large array of proteins that perform enzymatic reactions on DNA, targeting and orchestrating their functions. In recent years there have been a large number of studies that have analyzed the structural details of how sliding clamps interact with their ligands. However, much remains to be learned in relation to how these interactions are regulated to occur coordinately and sequentially. Since sliding clamps participate in reactions in which many different enzymes bind and then release from the clamp in an orchestrated way, it is critical to analyze how these changes in affinity take place. In this review I focus the attention on the mechanisms by which various types of enzymes interact with sliding clamps and what is known about the regulation of this binding. Especially I describe emerging paradigms on how enzymes switch places on sliding clamps during DNA replication and repair of prokaryotic and eukaryotic genomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.