ArticleNature genetics2009
Comparative genomic and phylogeographic analysis of Mycobacterium leprae.
Article in Nature genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 166 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
166 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Leprosy in skeletons from archaeological sites: A systematic review.PLoS neglected tropical diseases · 2025Pooled it
- Trial
- Two pathogens, one disease: Rethinking leprosy diversification through ancient and modern genomes.Clinical and translational medicine · 2026Article
- Functional Annotation and Molecular Characterization of a Hypothetical Protein FromEvolutionary bioinformatics online · 2026Article
- British Red Squirrels (Interdisciplinary perspectives on infectious diseases · 2026Article
- Is dUTPase Enzymatic Activity Truly Essential for Viability?International journal of molecular sciences · 2025Review
- Lepromatous leprosy in Bronze Age Oman: micro-CT provides tools for paleopathology in fragmentary and commingled assemblages.Frontiers in medicine · 2025Article
- Leprosy.Nature reviews. Disease primers · 2024Review
- Genomic and Phenotypic Variations Among Thai-53 andPathogens (Basel, Switzerland) · 2024Article
- Successful Allogeneic Hematopoietic Cell Transplantation for Patients with IL10RA Deficiency in Japan.Journal of clinical immunology · 2024Article
- Genetic diversity of Mycobacterium leprae: Need to move towards genome-wide approaches.The Indian journal of medical research · 2024Review
- Review
- Challenges Experienced and Observed during the Implementation of Leprosy Strategies, Sidama Region, Southern Ethiopia: An inductive thematic analysis of qualitative study among health professionals who working with leprosy programs.PLoS neglected tropical diseases · 2023Article
- Genotyping ofIranian journal of microbiology · 2023Article
- Mycobacterium leprae in Armadillo Tissues from Museum Collections, United States.Emerging infectious diseases · 2023Article
- Climate change, human health, and resilience in the Holocene.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Genetic diversity of Mycobacterium leprae in the state of São Paulo, an area of low-leprosy incidence in Brazil.Revista da Sociedade Brasileira de Medicina Tropical · 2023Article
- Pathogenicity and virulence ofVirulence · 2022Review
- Genomics of Ancient Pathogens: First Advances and Prospects.Biochemistry. Biokhimiia · 2022Review
- Evidente-a visual analytics tool for data enrichment in SNP-based phylogenetic trees.Bioinformatics advances · 2022Article
106 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issuedKhamispour, Ali [corrected to Khamesipour, Ali]
Authors and funding
32 authors.
Funding
Abstract
Reductive evolution and massive pseudogene formation have shaped the 3.31-Mb genome of Mycobacterium leprae, an unculturable obligate pathogen that causes leprosy in humans. The complete genome sequence of M. leprae strain Br4923 from Brazil was obtained by conventional methods (6x coverage), and Illumina resequencing technology was used to obtain the sequences of strains Thai53 (38x coverage) and NHDP63 (46x coverage) from Thailand and the United States, respectively. Whole-genome comparisons with the previously sequenced TN strain from India revealed that the four strains share 99.995% sequence identity and differ only in 215 polymorphic sites, mainly SNPs, and by 5 pseudogenes. Sixteen interrelated SNP subtypes were defined by genotyping both extant and extinct strains of M. leprae from around the world. The 16 SNP subtypes showed a strong geographical association that reflects the migration patterns of early humans and trade routes, with the Silk Road linking Europe to China having contributed to the spread of leprosy.
Indexed as
Identifiers
19881526What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.