ArticleNature immunology2009
Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitment.
Article in Nature immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 54 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 92 citations in OpenAlex.
- CpG content contributes to tissue-resident macrophage enhancer selection.Nucleic acids research · 2026Article
- BHLHE41, a transcriptional repressor involved in physiological processes and tumor development.Cellular oncology (Dordrecht, Netherlands) · 2025Review
- Role of differentiated embryo-chondrocyte expressed gene 2 in immunity.Frontiers in immunology · 2024Review
- In vitro modeling of CD8Science immunology · 2023Article
- Approach to Functions ofInternational journal of molecular sciences · 2023Review
- Article
- Identification of novel B-1 transitional progenitors by B-1 lymphocyte fate-mapping transgenic mouse modelFrontiers in immunology · 2022Article
- BHLHE41/DEC2 Expression Induces Autophagic Cell Death in Lung Cancer Cells and Is Associated with Favorable Prognosis for Patients with Lung Adenocarcinoma.International journal of molecular sciences · 2021Article
- The Potential Roles of Dec1 and Dec2 in Periodontal Inflammation.International journal of molecular sciences · 2021Review
- Transcription Factor Bhlhe40 in Immunity and Autoimmunity.Trends in immunology · 2020Review
- Single cell RNA-sequencing identified Dec2 as a suppressive factor for spermatogonial differentiation by inhibiting Sohlh1 expression.Scientific reports · 2019Article
- Loss of the basic helix-loop-helix transcription factor Bhlhe41 induces cell death and impairs neurite outgrowth in Neuro2a cells.Molecular and cellular biochemistry · 2019Article
- Crucial Role of Increased Arid3a at the Pre-B and Immature B Cell Stages for B1a Cell Generation.Frontiers in immunology · 2019Article
- Transcriptional regulation of CD4Journal of leukocyte biology · 2018Review
- USP38 critically promotes asthmatic pathogenesis by stabilizing JunB protein.The Journal of experimental medicine · 2018Article
- Monocyte chemotactic protein-induced protein 1 controls allergic airway inflammation by suppressing IL-5-producing TThe Journal of allergy and clinical immunology · 2018Article
- The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia.Nature communications · 2018Article
- Analysis of high-resolution 3D intrachromosomal interactions aided by Bayesian network modeling.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Regulation of B-1a cells: another novel function of the basic helix-loop-helix transcriptional regulator BHLHE41.Cellular & molecular immunology · 2017Article
- DEC2 Blocks the Effect of the ARNTL2/NPAS2 Dimer on the Expression of PER3 and DBP.Journal of circadian rhythms · 2017Article
Corrections and comments
- Erratum issued
Authors and funding
11 authors at 6 institutions in 3 countries.
Funding
Abstract
How naive CD4(+) T cells commit to the T helper type 2 (T(H)2) lineage is poorly understood. Here we show that the basic helix-loop-helix transcription factor Dec2 was selectively expressed in T(H)2 cells. CD4(+) T cells from Dec2-deficient mice showed defective T(H)2 differentiation in vitro and in vivo in an asthma model and in response to challenge with a parasite antigen. Dec2 promoted expression of interleukin 4 (IL-4), IL-5 and IL-13 during early T(H)2 differentiation and directly bound to and activated transcription of genes encoding the transcription factors JunB and GATA-3. As GATA-3 induces Dec2 expression, our findings also indicate a feed-forward regulatory circuit during T(H)2 differentiation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.