ArticleThe Plant cell2009
A population genomics study of the Arabidopsis core cell cycle genes shows the signature of natural selection.
Article in The Plant cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 24 citations in OpenAlex.
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- Divergence of a genomic island leads to the evolution of melanization in a halophyte root fungus.The ISME journal · 2021Article
- Evolution of meiotic recombination genes in maize and teosinte.BMC genomics · 2017Article
- Article
- Genes involved in floral meristem in tomato exhibit drastically reduced genetic diversity and signature of selection.BMC plant biology · 2014Article
- Genome-scale cold stress response regulatory networks in ten Arabidopsis thaliana ecotypes.BMC genomics · 2013Article
- Identification of Arabidopsis meiotic cyclins reveals functional diversification among plant cyclin genes.PLoS genetics · 2013Article
- Combined linkage and association mapping reveals CYCD5;1 as a quantitative trait gene for endoreduplication in Arabidopsis.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Metabolic networks: how to identify key components in the regulation of metabolism and growth.Plant physiology · 2010Review
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Large-scale comparison of sequence polymorphism and divergence at numerous genomic loci within and between closely related species can reveal signatures of natural selection. Here, we present a population genomics study based on direct sequencing of 61 mitotic cell cycle genes from 30 Arabidopsis thaliana accessions and comparison of the resulting data to the close relative Arabidopsis lyrata. We found that the Arabidopsis core cell cycle (CCC) machinery is not highly constrained but is subject to different modes of selection. We found patterns of purifying selection for the cyclin-dependent kinase (CDK), CDK subunit, retinoblastoma, and WEE1 gene families. Other CCC gene families often showed a mix of one or two constrained genes and relaxed purifying selection on the other genes. We found several large effect mutations in CDKB1;2 that segregate in the species. We found a strong signature of adaptive protein evolution in the Kip-related protein KRP6 and departures from equilibrium at CDKD;1 and CYCA3;3 consistent with the operation of selection in these gene regions. Our data suggest that within Arabidopsis, the genetic robustness of cell cycle-related processes is more due to functional redundancy than high selective constraint.
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