ArticleProceedings of the National Academy of Sciences of the United States of America2009
Dynamic bookmarking of primary response genes by p300 and RNA polymerase II complexes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed, 60 citations in OpenAlex.
- Coordinated histone H3 methylation and acetylation regulate physiologic and pathologic fas ligand gene expression in human CD4+ T cells.Journal of immunology (Baltimore, Md. : 1950) · 2014Trial
- Epigenetic mechanisms of inflammatory memory in the central nervous system.Nature immunology · 2026Review
- A proximity-induced chimera platform for targeted protein arginine methylation.Acta pharmaceutica Sinica. B · 2025Article
- The roles of inducible chromatin and transcriptional memory in cellular defense system responses to redox-active pollutants.Free radical biology & medicine · 2021Review
- Ebola Virus VP40 Modulates Cell Cycle and Biogenesis of Extracellular Vesicles.The Journal of infectious diseases · 2018Article
- CpG island composition differences are a source of gene expression noise indicative of promoter responsiveness.Genome biology · 2018Article
- TT-seq captures enhancer landscapes immediately after T-cell stimulation.Molecular systems biology · 2017Article
- Polycomb inhibits histone acetylation by CBP by binding directly to its catalytic domain.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- BTB-ZF transcriptional regulator PLZF modifies chromatin to restrain inflammatory signaling programs.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Cell cycle-dependent changes in H3K56ac in human cells.Cell cycle (Georgetown, Tex.) · 2015Article
- Epigenetic inheritance: histone bookmarks across generations.Trends in cell biology · 2014Review
- BET Inhibitor JQ1 Blocks Inflammation and Bone Destruction.Journal of dental research · 2014Article
- A dual role for the histone methyltransferase PR-SET7/SETD8 and histone H4 lysine 20 monomethylation in the local regulation of RNA polymerase II pausing.The Journal of biological chemistry · 2014Article
- Promoter-bound p300 complexes facilitate post-mitotic transmission of transcriptional memory.PloS one · 2014Article
- Short-term memory of danger signals and environmental stimuli in immune cells.Nature immunology · 2013Article
- High expression levels of COX-2 and P300 are associated with unfavorable survival in laryngeal squamous cell carcinoma.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2013Article
- The intronic long noncoding RNA ANRASSF1 recruits PRC2 to the RASSF1A promoter, reducing the expression of RASSF1A and increasing cell proliferation.PLoS genetics · 2013Article
- Lysine acetyltransferases CBP and p300 as therapeutic targets in cognitive and neurodegenerative disorders.Current pharmaceutical design · 2013Review
- Activation of tachykinin, neurokinin 3 receptors affects chromatin structure and gene expression by means of histone acetylation.Peptides · 2012Article
Corrections and comments
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Authors and funding
17 authors at 4 institutions in 2 countries.
Funding
Abstract
Profiling the dynamic interaction of p300 with proximal promoters of human T cells identified a class of genes that rapidly coassemble p300 and RNA polymerase II (pol II) following mitogen stimulation. Several of these p300 targets are immediate early genes, including FOS, implicating a prominent role for p300 in the control of primary genetic responses. The recruitment of p300 and pol II rapidly transitions to the assembly of several elongation factors, including the positive transcriptional elongation factor (P-TEFb), the bromodomain-containing protein (BRD4), and the elongin-like eleven nineteen lysine-rich leukemia protein (ELL). However, transcription at many of these rapidly induced genes is transient, wherein swift departure of P-TEFb, BRD4, and ELL coincides with termination of transcriptional elongation. Unexpectedly, both p300 and pol II remain accumulated or "bookmarked" at the proximal promoter long after transcription has terminated, demarking a clear mechanistic separation between the recruitment and elongation phases of transcription in vivo. The bookmarked pol II is depleted of both serine-2 and serine-5 phosphorylation of its C-terminal domain and remains proximally positioned at the promoter for hours. Surprisingly, these p300/pol II bookmarked genes can be readily reactivated, and elongation factors can be reassembled by subsequent addition of nonmitogenic agents that, alone, have minimal effects on transcription in the absence of prior preconditioning by mitogen stimulation. These findings suggest that p300 is likely to play an important role in biological processes in which transcriptional bookmarking or preconditioning influences cellular growth and development through the dynamic priming of genes for response to rechallenge by secondary stimuli.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.