ArticleDiabetes care2010
Proinflammatory modulation of the surface and cytokine phenotype of monocytes in patients with acute Charcot foot.
Article in Diabetes care, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.
- Treatment of acute Charcot foot with bisphosphonates: a systematic review of the literature.Diabetologia · 2012Pooled it
- Monocytes Display Altered Inflammatory Profiles in Individuals with Diabetic Foot Ulcers Indicating Monocyte Dysfunction.European journal of immunology · 2026Article
- Association of inflammation and nutrition-based indicators and diabetic foot ulcers: a cross-sectional study and a retrospective study.Frontiers in endocrinology · 2025Article
- PATHOGENESIS OF ACUTE DIABETIC CHARCOT ARTHROPATHY IN THE FOOT AND ANKLE: A COMPREHENSIVE LITERATURE REVIEW.Orthopedic reviews · 2025Article
- Rare complication of rheumatoid arthritis: Charcot Neuro-osteoarthropathy.BMC musculoskeletal disorders · 2024Article
- Novel Biomarkers Predictive of Diabetic Charcot Foot-An Overview of the Literature.Life (Basel, Switzerland) · 2022Review
- Effect of Kidney Transplantation on Accelerated Immunosenescence and Vascular Changes Induced by Chronic Kidney Disease.Frontiers in medicine · 2021Article
- An overview of Charcot's neuroarthropathy.Journal of clinical & translational endocrinology · 2020Review
- Initial Diagnosis and Management for Acute Charcot Neuroarthropathy.Kansas journal of medicine · 2018Review
- Differentially expressed circulating microRNAs in the development of acute diabetic Charcot foot.Epigenomics · 2018Article
- Updates on Diabetic Foot and Charcot Osteopathic Arthropathy.Current diabetes reports · 2018Review
- Neuroarthropathy in diabetes: pathogenesis of Charcot arthropathy.Bone & joint research · 2018Article
- Markers of Local Inflammation and Bone Resorption in the Acute Diabetic Charcot Foot.Journal of diabetes research · 2018Article
- Ligation of Na, K ATPase β3 subunit on monocytes by a specific monoclonal antibody mediates T cell hypofunction.PloS one · 2018Article
- Diabetic Neuropathy and Gait: A Review.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2017Review
- Circulating microparticles in acute diabetic Charcot foot exhibit a high content of inflammatory cytokines, and support monocyte-to-osteoclast cell induction.Scientific reports · 2017Article
- Pathogenesis and potential relative risk factors of diabetic neuropathic osteoarthropathy.Journal of orthopaedic surgery and research · 2017Review
- Endophenotype Network Models: Common Core of Complex Diseases.Scientific reports · 2016Article
- Neuropathic osteoarthropathy with and without superimposed osteomyelitis in patients with a diabetic foot.Skeletal radiology · 2016Review
- Expression of the receptor activator of nuclear factor-kB ligand in peripheral blood mononuclear cells in patients with acute Charcot neuroarthropathy.International journal of medical sciences · 2016Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveDespite increased information on the importance of an inappropriate inflammatory response in the acute Charcot process, there has been no previous attempt to define the specific pathways that mediate its pathogenesis. Here, the role played by monocytes was analyzed. RESEARCH DESIGN AND
methodsThe immune phenotype of peripheral monocytes was studied by fluorescence-activated cell sorter analysis comparing patients with acute Charcot (n = 10) in both the active and recovered phase, diabetic patients with neuropathy (with or without osteomyelitis), and normal control subjects.
resultsWhen compared with diabetic control subjects and healthy subjects, monocytes from acute Charcot patients showed a proinflammatory immune phenotype characterized by increased production of proinflammatory cytokines, reduced secretion of anti-inflammatory cytokines, increased expression of surface costimulatory molecules, and increased resistance to serum withdrawal-induced apoptosis. In addition, the pattern of circulating cytokines confirmed activation of proinflammatory cytokines. No modulation of the monocyte phenotype was documented in diabetic control subjects and healthy subjects, thus indicating that the proinflammatory alterations of monocytes are specific and causative of acute Charcot.
conclusionsTogether, these data provide evidence for the role of proinflammatory changes in the immune phenotype of monocytes in the pathogenesis of acute Charcot. These alterations may explain the abnormally intense and prolonged inflammatory response that characterizes this disorder and may represent a potential therapeutic target for specific pharmacological interventions.
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