ArticleJournal of leukocyte biology2010
Leukotriene B4 mediates gammadelta T lymphocyte migration in response to diverse stimuli.
Article in Journal of leukocyte biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- Specialized pro-resolving receptors are expressed in salivary glands with Sjögren's syndrome.Annals of diagnostic pathology · 2022Article
- Identification and validation of immune cells and hub genes alterations in recurrent implantation failure: A GEO data mining study.Frontiers in genetics · 2022Article
- Baseline Elevations of Leukotriene Metabolites and Altered Plasmalogens Are Prognostic Biomarkers of Plaque Progression in Systemic Lupus Erythematosus.Frontiers in cardiovascular medicine · 2022Article
- Eicosanoid and Specialized Proresolving Mediator Regulation of Lymphoid Cells.Trends in biochemical sciences · 2019Review
- Resolvin E1 attenuates murine psoriatic dermatitis.Scientific reports · 2018Article
- The role of the LTBSeminars in immunology · 2017Review
- The cannabinoid 2 receptor agonist β-caryophyllene modulates the inflammatory reaction induced by Mycobacterium bovis BCG by inhibiting neutrophil migration.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2016Article
- Differential Contribution of BLT1 and BLT2 to Leukotriene B4-Induced Human NK Cell Cytotoxicity and Migration.Mediators of inflammation · 2015Article
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- Polyunsaturated Fatty Acid-derived lipid mediators and T cell function.Frontiers in immunology · 2014Review
- A role for 5-lipoxygenase products in obesity-associated inflammation and insulin resistance.Adipocyte · 2013Article
- Adipocytes secrete leukotrienes: contribution to obesity-associated inflammation and insulin resistance in mice.Diabetes · 2012Article
- Fatty acids induce leukotriene C4 synthesis in macrophages in a fatty acid binding protein-dependent manner.Biochimica et biophysica acta · 2012Article
- 5-Lipoxygenase deficiency impairs innate and adaptive immune responses during fungal infection.PloS one · 2012Article
- γδ T Lymphocytes Coordinate Eosinophil Influx during Allergic Responses.Frontiers in pharmacology · 2012Article
- Eicosanoids and respiratory viral infection: coordinators of inflammation and potential therapeutic targets.Mediators of inflammation · 2012Review
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- Leukotrienes target F-actin/cofilin-1 to enhance alveolar macrophage anti-fungal activity.The Journal of biological chemistry · 2011Article
- Viral cell death inhibitor MC159 enhances innate immunity against vaccinia virus infection.Journal of virology · 2010Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Herein, we investigated the involvement of the 5-LO-derived lipid mediator LTB(4) in gammadelta T cell migration. When injected into the i.pl. space of C57BL/6 mice, LTB(4) triggered gammadelta T lymphocyte mobilization in vivo, a phenomenon also observed in in vitro chemotaxis assays. The i.pl. injection of Escherichia coli endotoxin (LPS) triggered increased levels of LTB(4) in pleural cavities. The in vivo inhibition of LTB(4) biosynthesis by the 5-LO inhibitor zileuton or the FLAP inhibitor MK886 attenuated LPS-induced gammadelta T cell accumulation into pleural cavities. Accordingly, 5-LO KO mice failed to recruit gammadelta T cells into the inflammatory site after i.pl. LPS. Antagonists of the high-affinity LTB(4) receptor BLT1, CP105,696, and LY292476 also attenuated LPS-induced gammadelta T cell accumulation in pleural cavities as well as in vitro chemotaxis toward pleural washes obtained from LPS-simulated mice. LTB(4)/BLT1 also accounted for gammadelta T cell migration induced by i.pl. administration of Mycobacterium bovis BCG or antigen in sensitized mice. BLT1 was expressed on naïve, resident as well as LPS-recruited gammadelta T cells. Isolated gammadelta T cells were found to undergo F-actin cytoskeleton reorganization when incubated with LTB(4) in vitro, confirming that gammadelta T lymphocytes can respond directly to LTB(4). In addition to its direct effect on gammadelta T cells, LTB(4) triggered their accumulation indirectly, via modulation of CCL2 production in mouse pleural cavities. These data show that gammadelta T cell migration into the pleural cavity of mice during diverse inflammatory responses is dependent on LTB(4)/BLT1.
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