ArticleDNA research : an international journal for rapid publication of reports on genes and genomes2009
Identification and functional analyses of 11,769 full-length human cDNAs focused on alternative splicing.
Article in DNA research : an international journal for rapid publication of reports on genes and genomes, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Pathogenic Variants inNeurology. Genetics · 2025Article
- Review
- Expression of murine muscle-enriched A-type lamin-interacting protein (MLIP) is regulated by tissue-specific alternative transcription start sites.The Journal of biological chemistry · 2018Article
- An Insight into the Increasing Role of LncRNAs in the Pathogenesis of Gliomas.Frontiers in molecular neuroscience · 2017Review
- Transcriptome survey reveals increased complexity of the alternative splicing landscape in Arabidopsis.Genome research · 2012Article
- Genome-wide determination of RNA stability reveals hundreds of short-lived noncoding transcripts in mammals.Genome research · 2012Article
- Identification and characterization of novel genotoxic stress-inducible nuclear long noncoding RNAs in mammalian cells.PloS one · 2012Article
- Identification of a novel muscle A-type lamin-interacting protein (MLIP).The Journal of biological chemistry · 2011Article
- The ubiquitous dermokine delta activates Rab5 function in the early endocytic pathway.PloS one · 2011Article
Corrections and comments
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Authors and funding
7 authors.
Funding
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Abstract
We analyzed diversity of mRNA produced as a result of alternative splicing in order to evaluate gene function. First, we predicted the number of human genes transcribed into protein-coding mRNAs by using the sequence information of full-length cDNAs and 5'-ESTs and obtained 23 241 of such human genes. Next, using these genes, we analyzed the mRNA diversity and consequently sequenced and identified 11 769 human full-length cDNAs whose predicted open reading frames were different from other known full-length cDNAs. Especially, 30% of the cDNAs we identified contained variation in the transcription start site (TSS). Our analysis, which particularly focused on multiple variable first exons (FEVs) formed due to the alternative utilization of TSSs, led to the identification of 261 FEVs expressed in the tissue-specific manner. Quantification of the expression profiles of 13 genes by real-time PCR analysis further confirmed the tissue-specific expression of FEVs, e.g. OXR1 had specific TSS in brain and tumor tissues, and so on. Finally, based on the results of our mRNA diversity analysis, we have created the FLJ Human cDNA Database. From our result, it has been understood mechanisms that one gene produces suitable protein-coding transcripts responding to the situation and the environment.
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