ArticleAtherosclerosis2010
Anti-atherosclerotic actions of azelaic acid, an end product of linoleic acid peroxidation, in mice.
Article in Atherosclerosis, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 52 citations in OpenAlex.
- Alcohol-related liver disease disrupts bile acid homeostasis and gut microbial bile acid metabolism.JHEP reports : innovation in hepatology · 2026Article
- Commemorating Dr. Sampath (Sam) Parthasarathy for his Exceptional Research in Biochemistry and Lipidology in Health and Diseaseand Legacy as a Superb Mentor and Scientist.Cell biochemistry and biophysics · 2026Article
- Thermochemolysis-gas chromatographic detection of oxidized fatty acids in a single Drosophila melanogaster individual.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2026Article
- Odd-Chain Dicarboxylic Acid Feeding Produces a Glutaric Aciduria Type 1-Like Metabolic Signature in Mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- MSI.EAGLE: An Open-Source GUI for Streamlined Mass Spectrometry Imaging Analysis.bioRxiv : the preprint server for biology · 2025Article
- Multi-omics analysis revealed biomarkers for coronary atherosclerosis: Occurrence and development.Clinical and translational medicine · 2025Article
- The Pathophysiological Basis of Diabetic Kidney Protection by Inhibition of SGLT2 and SGLT1.Kidney and dialysis · 2022Article
- Characterization of fecal metabolome changes in patients with obstructive sleep apnea.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Article
- Article
- Intestinal and Hepatic Uptake of Dietary Peroxidized Lipids and Their Decomposition Products, and Their Subsequent Effects on Apolipoprotein A1 and Paraoxonase1.Antioxidants (Basel, Switzerland) · 2021Article
- Metabolic profiling reveals interleukin-17A monoclonal antibody treatment ameliorate lipids metabolism with the potentiality to reduce cardiovascular risk in psoriasis patients.Lipids in health and disease · 2021Article
- A role for tubular NaAmerican journal of physiology. Renal physiology · 2020Article
- Azelaic Acid Induces Mitochondrial Biogenesis in Skeletal Muscle by Activation of Olfactory Receptor 544.Frontiers in physiology · 2020Article
- Uncovering sperm metabolome to discover biomarkers for bull fertility.BMC genomics · 2019Article
- Evaluation of Anti-Inflammatory Properties of Herbal Aqueous Extracts and Their Chemical Characterization.Journal of medicinal food · 2019Article
- In Schizophrenia, Deficits in Natural IgM Isotype Antibodies Including those Directed to Malondialdehyde and Azelaic Acid Strongly Predict Negative Symptoms, Neurocognitive Impairments, and the Deficit Syndrome.Molecular neurobiology · 2019Article
- Primary prevention of atherosclerosis by pretreatment of low-density lipoprotein receptor knockout mice with sesame oil and its aqueous components.Scientific reports · 2018Article
- A Novel Mechanism for Atherosclerotic Calcification: Potential Resolution of the Oxidation Paradox.Antioxidants & redox signaling · 2018Article
- Modulatory effect of linoleic and oleic acid on cell proliferation and lipid metabolism gene expressions in primary bovine satellite cells.Animal cells and systems · 2018Article
- Olfactory receptor 544 reduces adiposity by steering fuel preference toward fats.The Journal of clinical investigation · 2017Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAtherosclerosis is a chronic inflammatory disease associated with the accumulation of oxidized lipids in arterial lesions. Recently we studied the degradation of peroxidized linoleic acid and suggested that oxidation is an essential process that results in the generation of terminal products, namely mono- and dicarboxylic acids that may lack the pro-atherogenic effects of peroxidized lipids. In continuation of that study, we tested the effects of azelaic acid (AzA), one of the end products of linoleic acid peroxidation, on the development of atherosclerosis using low density lipoprotein receptor knockout (LDLr(-/-)) mice. METHODS AND
resultsLDLr(-/-) mice were fed with a high fat and high cholesterol Western diet (WD group). Another group of animals were fed the same diet with AzA supplementation (WD+AzA group). After 4 months of feeding, mice were sacrificed and atherosclerotic lesions were measured. The results showed that the average lesion area in WD+AzA group was 38% (p<0.001) less as compared to WD group. The athero-protective effect of AzA was not related to changes in plasma lipid content. AzA supplementation decreased the level of CD68 macrophage marker by 34% (p<0.05).
conclusionsThe finding that AzA exhibits an anti-atherogenic effect suggests that oxidation of lipid peroxidation-derived aldehydes into carboxylic acids could be an important step in the body's defense against oxidative damage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.